Thus, the microarray patterns from two different siRNAs targeting the same mRNA may be identical, but the siRNAs could still have differential effects through translational inhibition. With all of the READ MORE http://www.genengnews.com/rnai/rnai_supp_1.aspx
Length of cell exposure to transfection agents should be optimized to minimize cellular toxicity and maximize siRNA activity by varying the amount of transfection agent and cell exposure time to trans READ MORE http://www.ambion.com/techlib/tn/121/9.html
Finally, since RNAi directed against HPV18 E6/E7 has been reported to cause cellular senescence in HeLa cells (4), we monitored the typical senescence-associated spindly-cell and large-cell morphology READ MORE http://find.galegroup.com/ips/retrieve.do...
Intradigm (Rockville, Maryland, USA) has developed non-viral delivery systems for intratumoral administration of siRNA into several xenograft tumor models to knock down angiogenesis factors, resulting READ MORE http://find.galegroup.com/ips/retrieve.do...
Delivery strategies for siRNA-mediated gene silencing.
April 2006
Gilmore IR, Fox SP, Hollins AJ, Akhtar S.
PubMed
RNA interference (RNAi) represents a promising new gene silencing technology fo READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
siRNA-based approaches in cancer therapy.
2006 Jan 20
Devi GR.
PubMed
The availability of the human genome sequence has revolutionized the strategy of employing nucleic acids with sequences comp READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity.
2006 Jan-Feb
Matsui K, Horiuchi READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
New patent to enhance Sirna?s RNA production
January 30, 2006
Kirsty Barnes
In-pharma
Sirna Therapeutics has been granted a US patent covering a more efficient process for the chemical synthesis READ MORE http://www.in-pharmatechnologist.com/news/ng.asp...
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
January 7, 2003
Xiao-Feng Qin, Dong Sung An,Irvin S. Y. Chen, and David Baltimore
READ MORE http://www.pnas.org/cgi/content/full/100/1/183
Phase II Trial Starts for siRNA Therapy for Wet AMD
October 19, 2005
Genetic Engineering News
Acuity Pharmaceuticals initiated a Phase II trial for Cand5, its lead product candidate for the treatme READ MORE http://www.genengnews.com/stickyends/article.aspx...
siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
15 May 2006
Chunling Zhanga, Ning Tanga,, XingJun Liua, Wei Lianga, , , Wei Xua and Vladimir P. Torchili READ MORE http://www.sciencedirect.com/science...
A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication
Available online 11 May 2006.
Ellen M. Westerhout, Monique Vink, P.C. Joost Haasnoo READ MORE http://www.sciencedirect.com/science...
rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse
28 April 2006
Yoko Machidaa, Takashi Okadab, Masaru Kurosawaa, Fumitaka Oyamaa, Keiya Ozawab and Nobuyuki Nukina
B READ MORE http://www.sciencedirect.com/science...
Acuity Pharmaceuticals Reports Positive Initial Phase II Results For Bevasiranib (Cand5) In Wet AMD
June 2, 2006
Acuity Pharmaceuticals
Acuity Pharmaceuticals, an ophthalmic pharmaceutical compan READ MORE http://www.acuitypharma.com/press.asp
RNAi Global Initiative Members Advance Standards For Genome-Wide RNAi Research In Second Meeting
May 24, 2006
Dharmacon
The Genome-Wide RNAi Global Initiative (RNAi Global), an alliance of Dharmaco READ MORE http://www.dharmacon.com/company/pressrelease.aspx...
SR Pharma plc Announces a Key Technical Breakthrough With its Lyophilized (Dry Powder) Liposomal-Based siRNA Formulation
June 6, 2006
Sr Pharma
LONDON, June 6 /PRNewswire/ -- SR Pharma plc (LSE: READ MORE http://www.srpharma.com/news/index.htm
DHARMACON and AMAXA COLLABORATE TO IMPROVE SiRNA DELIVERY INTO CELLS; Nucleofector Technology Enables siRNA Transfer into Primary Cells and Non-Standard Cell Lines
June 6, 2006
Dharmacon
LAFAYETT READ MORE http://www.dharmacon.com/company/pressrelease.aspx...
Demonstration of two novel methods for predicting functional siRNA efficiency
29 May 2006
PeiLin Jia , TieLiu Shi , YuDong Cai , YiXue Li
BMC Bioinformatics
Abstract (provisional)
Background
READ MORE http://www.biomedcentral.com/1471-2105/7/271
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
December 23, 2004
B Urban-Klein, S Werth, S Abuharbeid, F Czubayko and A Aigner
Gene Ther READ MORE http://www.nature.com/gt/journal/v12/n5/abs/3302425a.html
Alnylam Receives New Issued U.S. Patent Broadly Covering Small Interfering RNAs and Strengthens Leadership in Intellectual Property for RNAi Therapeutics
July 18, 2006
CAMBRIDGE, Mass.--(BUSINES READ MORE http://phx.corporate-ir.net/phoenix.zhtml...
PEG conjugated VEGF siRNA for anti-angiogenic gene therapy
2006
Sun Hwa Kima, Ji Hoon Jeongb, Soo Hyun Leea, Sung Wan Kimb and Tae Gwan Park
Journal of Controlled Release
Abstract
A novel siRN READ MORE http://www.sciencedirect.com/science...
Organic?inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer
10 April 2006
Yoshinori Kakizawaa, Sanae Furukawaa, Atushi Ish READ MORE http://www.sciencedirect.com/science...
Transporting silence: Design of carriers for siRNA to angiogenic endothelium
5 December 2005
Raymond M. Schiffelersa, , , Archibald J. Mixsonb, Aslam M. Ansaric, Marcel H.A.M. Fensa, Quingquan Tan READ MORE http://www.sciencedirect.com/science...
Transfection microarray of human mesenchymal stem cells and on-chip siRNA gene knockdown
28 April 2004
Tomohiro Yoshikawa a, Eiichiro Uchimura a, Michiko Kishi a, Daniel P. Funeriu a, Masato Miyak READ MORE http://www.sciencedirect.com/science...
Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery
18 June 2004
Yoshinori Kakizawaa, Sanae Furukawaa and Kazunori READ MORE http://www.sciencedirect.com/science...
Highly effective inhibition of Akabane virus replication by siRNA genes
September 2006
Aviad Levinb, Larisa Kutznetovaa, Ronen Kahanaa, Marisol Rubinstein-Guinia and Yehuda Stram
Virus Research
READ MORE http://www.sciencedirect.com/science...
Developing new SiRNA-based therapeutics
August 17, 2006
Laboratorytalk
Perbio Science reports that Abbott and Dharmacon has announced a collaboration to develop new therapeutic agents based on a READ MORE http://www.laboratorytalk.com/news/pei/pei105.html
Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy
2006
Halder J; Kamat AA; Landen CN; Han LY; Lutgendorf SK; Lin YG; M READ MORE http://www.medscape.com/medline/abstract/16914580...
Can siRNA technology provide the tools for gene therapy of the future?
2006
Racz Z, Hamar P.
Curr Med Chem.
A new era in genetics has started 15 years ago, when co-suppression in petunia has be READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth
2006 Aug 15
Zhang Z, Yang X, Zhang Y, Z READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
The Long Processes of Short Interfering RNAs - RNA Interference and Its Implications in Neuronal Cells
2004
Lingor P, Michel U, Bahr M.
Neurodegener Dis.
Reverse genetics has been greatly advan READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
In vivo siRNA delivery to the mouse hypothalamus confirms distinct roles of TR beta isoforms in regulating TRH transcription
2006 Aug 21
Guissouma H, Froidevaux MS, Hassani Z, Demeneix BA.
Neuro READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
An effective method for adenoviral-mediated delivery of small interfering RNA into mesenchymal stem cells
2006 Aug 3
Forte A, Napolitano MA, Cipollaro M, Giordano A, Cascino A, Galderisi U.
J Ce READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
A peptidomimetic siRNA transfection reagent for highly effective gene silencing
2006 Jun
Utku Y, Dehan E, Ouerfelli O, Piano F, Zuckermann RN, Pagano M, Kirshenbaum K.
Mol Biosyst.
RNA interfe READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer
2006 Sep
Fujii T, Saito M, Iwasaki E, Ochiya T, Takei READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Ligand-Targeted Delivery of Therapeutic siRNA
2006 Jul 19
Ikeda Y, Taira K.
Pharm Res.
RNA interference (RNAi) is a post-transcriptional gene-silencing phenomenon that is triggered by double-s READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Nastech Wins Phase I SBIR Grant to Develop siRNA-Based Flu Drugs
August 29, 2006
GenomeWeb
NEW YORK (GenomeWeb News) ? Nastech Pharmaceutical has obtained a Phase I Small Business Innovation Res READ MORE http://www.genomeweb.com/issues/news/134715-1.html
Invitrogen Introduces Next Generation of Transfection Reagents; Lipofectamine(TM) LTX Reagent Improves DNA Delivery and Lowers Toxicity
August 30, 2006
Invitrogen
CARLSBAD, Calif.--(BUSINESS WIR READ MORE http://phx.corporate-ir.net/phoenix.zhtml...
Nanoparticles Successfully Deliver Protein-Suppressing RNA-Based Therapies
9/3/2006
nanotechwire.com
Small pieces of nucleic acid, known as siRNAs (short interfering RNAs), can turn off the prod READ MORE http://nanotechwire.com/news.asp...
Increased sensitivity to chemotherapeutic drug by RNAi targeting Hsp701A in HepG2 cells
September 2006
Zhu Q, Zhang WG, Wang LF, Wang F, Zhang Y, Yang AG
PubMed
AIM: To investigate the effects o READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
An siRNA-based microbicide protects mice fromlethal herpes simplex virus 2 infection
January 2006
Deborah Palliser Dipanjan Chowdhury Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson,David M. Knipe READ MORE http://idp.med.ufl.edu/Core/Spring/6006/D7_HSV2.pdf.
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
December, 2005
MARC S. WEINBERG, LOUISA M. VILLENEUVE, ALI EHSANI, MOHA READ MORE http://www.rnajournal.org/cgi/content/abstract/12/2/256
Cleavage of the siRNA passenger strand during RISC assembly in human cells.
January 2006
Leuschner PJ, Ameres SL, Kueng S, Martinez J.
PubMed
A crucial step in the RNA interference (RNAi) pathwa READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
siRNA in human cells selectively localizes to target RNA sites
May 16, 2006
Svitlana Y. Berezhna, Lubica Supekova, Frantisek Supek, Peter G. Schultz, and Ashok A. Deniz
PNAS
Recent observations READ MORE http://www.pnas.org/cgi/content/abstract/103/20/7682...
Transglutaminase Participates in UVB-Induced Cell Death Pathways in Human Corneal Epithelial Cells
2006 Oct
Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC.
Invest Ophthalmol Vis S READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Nastech awarded grant for siRNA therapeutics for flu
08/30/2006
By Wai Lang Chu
DrugResearcher.com
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Nastech Pharmace READ MORE http://www.drugresearcher.com/news/ng.asp...