A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication Available online 11 May 2006. Ellen M. Westerhout, Monique Vink, P.C. Joost Haasnoo

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium 20 April 2006 A Santel, M Aleku, O Keil, J Endruschat, V Esche, G Fisch, S Dames, K L?ffler, M Fechtner, W

A peptidomimetic siRNA transfection reagent for highly effective gene silencing 2006 Jun Utku Y, Dehan E, Ouerfelli O, Piano F, Zuckermann RN, Pagano M, Kirshenbaum K. Mol Biosyst. RNA interfe

Acuity Pharmaceuticals Reports Positive Initial Phase II Results For Bevasiranib (Cand5) In Wet AMD June 2, 2006 Acuity Pharmaceuticals Acuity Pharmaceuticals, an ophthalmic pharmaceutical compan

Alnylam Gets Issued U.S. Patent Broadly Covering RNAi Therapeutics - Quick Facts June 06, 2006; Trading Markets Live! RTTNews) - Alnylam Pharmaceuticals, Inc. (ALNY | charts | news | PowerRating

Alnylam Receives New Issued U.S. Patent Broadly Covering Small Interfering RNAs and Strengthens Leadership in Intellectual Property for RNAi Therapeutics July 18, 2006 CAMBRIDGE, Mass.--(BUSINES

An effective method for adenoviral-mediated delivery of small interfering RNA into mesenchymal stem cells 2006 Aug 3 Forte A, Napolitano MA, Cipollaro M, Giordano A, Cascino A, Galderisi U. J Ce

An siRNA-based microbicide protects mice fromlethal herpes simplex virus 2 infection January 2006 Deborah Palliser Dipanjan Chowdhury Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson,David M. Knipe

Thus, the microarray patterns from two different siRNAs targeting the same mRNA may be identical, but the siRNAs could still have differential effects through translational inhibition. With all of the

Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery 18 June 2004 Yoshinori Kakizawaa, Sanae Furukawaa and Kazunori

Calando Pharmaceuticals Selects Agilent Technologies For siRNA Production 7/26/06 Pharmaceutical Online Duarte & Palo Alto, CA - Calando Pharmaceuticals Inc., a majority-owned subsidiary of Arrow

Can siRNA technology provide the tools for gene therapy of the future? 2006 Racz Z, Hamar P. Curr Med Chem. A new era in genetics has started 15 years ago, when co-suppression in petunia has be

Complete article may be viewed online.

Cationized gelatin delivery of a plasmid DNA expressing small interference RNA for VEGF inhibits murine squamous cell carcinoma April 2006 Goichi Matsumoto, Toshihiro Kushibiki, Yukihiko Kinoshita

Cleavage of the siRNA passenger strand during RISC assembly in human cells. January 2006 Leuschner PJ, Ameres SL, Kueng S, Martinez J. PubMed A crucial step in the RNA interference (RNAi) pathwa

Intradigm (Rockville, Maryland, USA) has developed non-viral delivery systems for intratumoral administration of siRNA into several xenograft tumor models to knock down angiogenesis factors, resulting

Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth 2006 Aug 15 Zhang Z, Yang X, Zhang Y, Z

Delivery strategies for siRNA-mediated gene silencing. April 2006 Gilmore IR, Fox SP, Hollins AJ, Akhtar S. PubMed RNA interference (RNAi) represents a promising new gene silencing technology fo

Demonstration of two novel methods for predicting functional siRNA efficiency 29 May 2006 PeiLin Jia , TieLiu Shi , YuDong Cai , YiXue Li BMC Bioinformatics Abstract (provisional) Background

Designer siRNAs to overcome the challenges from the RNAi pathway February 2006 Sumedha D Jayasena Journal of RNAi and Gene Silencing ABSTRACT Small interfering RNA (siRNA)-based technology is

Developing new SiRNA-based therapeutics August 17, 2006 Laboratorytalk Perbio Science reports that Abbott and Dharmacon has announced a collaboration to develop new therapeutic agents based on a

DHARMACON and AMAXA COLLABORATE TO IMPROVE SiRNA DELIVERY INTO CELLS; Nucleofector Technology Enables siRNA Transfer into Primary Cells and Non-Standard Cell Lines June 6, 2006 Dharmacon LAFAYETT

Unlike other electroporators, which often require a minimum of 100,000 cells to achieve acceptable delivery and enough viable cells for analysis, we have found that the combination of our 96-well elec

Finally, since RNAi directed against HPV18 E6/E7 has been reported to cause cellular senescence in HeLa cells (4), we monitored the typical senescence-associated spindly-cell and large-cell morphology

Ex vivo and In vivo Delivery of Anti-Tissue Factor Short Interfering RNA Inhibits Mouse Pulmonary Metastasis of B16 Melanoma Cells July 1, 2006 Mohammed Amarzguioui1, Qian Peng2,3, Merete T. Wiige

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy 2006 Halder J; Kamat AA; Landen CN; Han LY; Lutgendorf SK; Lin YG; M

Highly effective inhibition of Akabane virus replication by siRNA genes September 2006 Aviad Levinb, Larisa Kutznetovaa, Ronen Kahanaa, Marisol Rubinstein-Guinia and Yehuda Stram Virus Research

In vivo siRNA delivery to the mouse hypothalamus confirms distinct roles of TR beta isoforms in regulating TRH transcription 2006 Aug 21 Guissouma H, Froidevaux MS, Hassani Z, Demeneix BA. Neuro

Increased sensitivity to chemotherapeutic drug by RNAi targeting Hsp701A in HepG2 cells September 2006 Zhu Q, Zhang WG, Wang LF, Wang F, Zhang Y, Yang AG PubMed AIM: To investigate the effects o

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 January 7, 2003 Xiao-Feng Qin, Dong Sung An,Irvin S. Y. Chen, and David Baltimore

Integrated DNA Technologies: Integrated DNA Technologies Acquires Belgian Manufacturer RNA-TEC 9/0/06 Bioresearch Online Purchase Expands IDT?s Large-Scale RNA Synthesis Capabilities; Builds Pres

Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer 2006 Sep Fujii T, Saito M, Iwasaki E, Ochiya T, Takei

Invitrogen Introduces Next Generation of Transfection Reagents; Lipofectamine(TM) LTX Reagent Improves DNA Delivery and Lowers Toxicity August 30, 2006 Invitrogen CARLSBAD, Calif.--(BUSINESS WIR

Ligand-Targeted Delivery of Therapeutic siRNA 2006 Jul 19 Ikeda Y, Taira K. Pharm Res. RNA interference (RNAi) is a post-transcriptional gene-silencing phenomenon that is triggered by double-s

Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels October 28, 2004 Zahra Hassani , Gregory F. Lemkine , Patrick Erbacher , Karima Palmi

Nanoparticles Successfully Deliver Protein-Suppressing RNA-Based Therapies 9/3/2006 nanotechwire.com Small pieces of nucleic acid, known as siRNAs (short interfering RNAs), can turn off the prod

Nastech awarded grant for siRNA therapeutics for flu 08/30/2006 By Wai Lang Chu DrugResearcher.com The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Nastech Pharmace

Nastech Wins Phase I SBIR Grant to Develop siRNA-Based Flu Drugs August 29, 2006 GenomeWeb NEW YORK (GenomeWeb News) ? Nastech Pharmaceutical has obtained a Phase I Small Business Innovation Res

New patent to enhance Sirna?s RNA production January 30, 2006 Kirsty Barnes In-pharma Sirna Therapeutics has been granted a US patent covering a more efficient process for the chemical synthesis

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice July 2, 2004 Donald Massaro,1 Gloria DeCarlo Massaro,2 and Linda Biadasz Clerch Am J Physiol Lung Cell

Length of cell exposure to transfection agents should be optimized to minimize cellular toxicity and maximize siRNA activity by varying the amount of transfection agent and cell exposure time to trans

Organic?inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer 10 April 2006 Yoshinori Kakizawaa, Sanae Furukawaa, Atushi Ish

Pathway Toward Gene Silencing Described In Plants 7/13/2006 Bioresearch Online Biologists at Washington University in St. Louis have made an important breakthrough in understanding a pathway

PEG conjugated VEGF siRNA for anti-angiogenic gene therapy 2006 Sun Hwa Kima, Ji Hoon Jeongb, Soo Hyun Leea, Sung Wan Kimb and Tae Gwan Park Journal of Controlled Release Abstract A novel siRN

Phase II Trial Starts for siRNA Therapy for Wet AMD October 19, 2005 Genetic Engineering News Acuity Pharmaceuticals initiated a Phase II trial for Cand5, its lead product candidate for the treatme

Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders 29 September 2005 P A Campochiaro Gene Therapy Abstract The eye is a relatively isolated ti

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse 28 April 2006 Yoko Machidaa, Takashi Okadab, Masaru Kurosawaa, Fumitaka Oyamaa, Keiya Ozawab and Nobuyuki Nukina B

RNAi Global Initiative Members Advance Standards For Genome-Wide RNAi Research In Second Meeting May 24, 2006 Dharmacon The Genome-Wide RNAi Global Initiative (RNAi Global), an alliance of Dharmaco

RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity. 2006 Jan-Feb Matsui K, Horiuchi

A weakness of the fusion proteins used by the authors is that purification and refolding steps are needed for each recombinant fusion protein. This might be addressed by the production of soluble anti

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo December 23, 2004 B Urban-Klein, S Werth, S Abuharbeid, F Czubayko and A Aigner Gene Ther

It also offers the flexibility to shuttle hairpin inserts from one vector to another depending on the researcher's needs. "There are different variations of plasmid vectors in terms of promoters and

Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma October 1, 2005 Siwen Hu-Liesk

siRNA in human cells selectively localizes to target RNA sites May 16, 2006 Svitlana Y. Berezhna, Lubica Supekova, Frantisek Supek, Peter G. Schultz, and Ashok A. Deniz PNAS Recent observations

siRNA-based approaches in cancer therapy. 2006 Jan 20 Devi GR. PubMed The availability of the human genome sequence has revolutionized the strategy of employing nucleic acids with sequences comp

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene 15 May 2006 Chunling Zhanga, Ning Tanga,, XingJun Liua, Wei Lianga, , , Wei Xua and Vladimir P. Torchili

SR Pharma plc Announces a Key Technical Breakthrough With its Lyophilized (Dry Powder) Liposomal-Based siRNA Formulation June 6, 2006 Sr Pharma LONDON, June 6 /PRNewswire/ -- SR Pharma plc (LSE:

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells December, 2005 MARC S. WEINBERG, LOUISA M. VILLENEUVE, ALI EHSANI, MOHA

The Long Processes of Short Interfering RNAs - RNA Interference and Its Implications in Neuronal Cells 2004 Lingor P, Michel U, Bahr M. Neurodegener Dis. Reverse genetics has been greatly advan

Therapeutic EphA2 Gene Targeting In vivo Using Neutral Liposomal Small Interfering RNA Delivery August 1, 2005 Charles N. Landen, Jr.1, Arturo Chavez-Reyes2, Corazon Bucana3, Rosemarie Schmandt1,

Transfection microarray of human mesenchymal stem cells and on-chip siRNA gene knockdown 28 April 2004 Tomohiro Yoshikawa a, Eiichiro Uchimura a, Michiko Kishi a, Daniel P. Funeriu a, Masato Miyak

Transglutaminase Participates in UVB-Induced Cell Death Pathways in Human Corneal Epithelial Cells 2006 Oct Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Invest Ophthalmol Vis S

Transporting silence: Design of carriers for siRNA to angiogenic endothelium 5 December 2005 Raymond M. Schiffelersa, , , Archibald J. Mixsonb, Aslam M. Ansaric, Marcel H.A.M. Fensa, Quingquan Tan

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity 2006 Jul Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS. RNA. Tran