A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline July 2006 Vasily V. Vagin, Alla Sigova, Chengjian Li, Herv? Seitz, Vladimir Gvozdev, Phillip D. Zamore Science In

A genomewide screen for components of the RNAi pathway in Drosophila cultured cells August 8, 2006 Silke Dorner, Lawrence Lum, Michelle Kim, Renato Paro, Philip A. Beachy, and Rachel Green PNAS

A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference 2006 Aug 10 Jia F, Zhang YZ, Liu CM. Biotechnol Lett. RNA interference (RNAi) might be an efficient antiv

A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression August 2006 Kum-Joo Shin , Estelle A. Wall, Joelle R. Zavzavadjian , Leah A

AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage. March 23, 2006 Wang X, Skelley L, Cade R, Sun Z. PubMed The aim of

Acquiring Actigenics, Cepheid Adds microRNA to Molecular Dx Business; Eyes Companion Dx Role By Doug Macron August 17, 2006 RNAi News Though Cepheid considers miRNAs to be ?very early-stage mar

Acuity Reports Positive Phase II Data for AMD Drug; Eyes Phase III in Mid-'07, NDA in Mid-'09 By Doug Macron September 14, 2006 RNAi News The company said that bevasiranib was safe and well-tol

After Delays, Nucleonics to Move Hep B Drug To Clinic in '07; Firm Unveils New Rx Goals 30 Nov 2006 RNAi News After struggling with optimization of its hepatitis B drug candidate, Nucleonics is n

After Reorganization, Intradigm Nabs VC Cash, New Brass, Calif. Home; Eyes Clinic in '07 November 22, 2006 By Doug Macron RNAi News While Intradigm had been flying under the radar for some time

Alnylam Advances a Systemically Delivered RNAi Therapeutic Targeting PCSK9 for the Treatment of Hypercholesterolemia as New Development Program December 5, 2006 Alnylam CAMBRIDGE, Mass.--(BUSINESS

Alnylam and INEX Accelerate Collaboration on Systemic Delivery of RNAi Therapeutics; Positive Results for Systemic RNAi Support Advancement to Next Phase of Collaboration July 17, 2008 Alnylam CAM

Alnylam Announces Collaboration with University of Texas Southwestern Medical Center to Discover RNAi Therapeutics for Hypercholesterolemia; Collaboration to Focus on PCSK9, a Key Gene Involved in M

Alnylam Gives Sneak Peek of Hypercholesterolemia Program at OTS Meeting; Additional Work Underway By Doug Macron October 26, 2006 RNAi News At the meeting, an Alnylam researcher presented some

Alnylam Picks PCSK9 Cholesterol Drug As Newest Candidate, Shelving apoB By Doug Macron December 7, 2006 RNAi News The company also said it expects that one of the two INDs it plans to file next

Alnylam Provides Details on Preclinical Neurology Programs at Society for Neuroscience Meeting By Doug Macron October 19, 2006 RNAi News The company provided new details about its preclinical w

Alnylam's Q2 Revenues Soar as Losses Decline; Firm Gives Update on Pipeline, microRNA Work By Doug Macron July 27, 2006 RNAi News The company remains on track to sign two more out-licensing dea

STAYING THE COURSE In light of these obstacles, several companies have abandoned their antisense efforts. Yet some are forging ahead. Recent clinical results, though largely preliminary, suggest thei

Antisense applications for biological control. May 2006 Pan WH, Clawson GA. Journal of Cell Biology Wiley Interscience Although Nature's antisense approaches are clearly impressive, this Perspe

Antiviral applications of RNAi. April 8, 2006 Morris KV, Rossi JJ. PubMed RNA interference (RNAi) is a natural mechanism by which small interfering RNA (siRNA) operates to specifically and poten

Antiviral RNAi therapy: emerging approaches for hitting a moving target 22 September 2005 J N Leonard and D V Schaffer Gene Therapy Abstract The field of directed RNA interference (RNAi) has ra

Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles February 2006 Yusuke Ohnishi, Katsushi Tokunaga, Kiyotoshi Kaneko and Hirohiko Hohjoh J

ATP-binding Cassette Transporters Are Required for Efficient RNA Interference in Caenorhabditis elegans August 2006 Prema Sundaram, Benjamin Echalier, Wang Han, Dawn Hull, and Lisa Timmons MBC O

Atugen Gives Update on Cancer Drugs; Firm Aims To Be First in Clinic as Phase I Is Set for 1H 2007 By Doug Macron November 2, 2006 RNAi News Atugen expects to begin phase I testing of its pancr

Autoimmune targeting of key components of RNA interference May 9, 2006 Andrew Jakymiw , Keigo Ikeda , Marvin J Fritzler, Westley H Reeves , Minoru Satoh and Edward KL Chan Arthritis Research and

Benitec Provides Additional Context on RNAi Study Published in Nature May 25, 2006 Benitec MOUNTAIN VIEW, Calif., May 25, 2006 /PRNewswire-FirstCall/ -- Benitec Ltd. , a leading developer of RNA

Benitec to Present at the American Society of Gene Therapy 9th Annual Meeting June 6, 2006 Benitec Ltd. MOUNTAIN VIEW, Calif., June 6 /PRNewswire-FirstCall/ -- Benitec Ltd. (ASX: BLT), a leading d

Benitec's Hepatitis C Drug Resurrected by Startup Company and Industry Veterans By Doug Macron October 12, 2006 RNAi News Tacere Therapeutics, whose name is Italian for ?to be silent,? was foun

Benitec's Share-Purchase Plan Fails to Raise Capital; Firm Restructures Deal with CSIRO By Doug Macron September 14, 2006 RNAi News The failure marks the end to one of the company?s strategies

Bio-Rad and IDT in deal to develop RNAi tools June 18, 2006 By Wai Lang Chu Bio-Rad Labs and Integrated DNA Technologies (IDT), have announced a collaboration to develop RNA interference (RNAi) t

BioDelivery Tech Used to Deliver Flu-Targeting siRNAs; Company Eyes Other RNAi Approaches By Doug Macron August 10, 2006 RNAi News The preclinical work was conducted by an undisclosed partner.

Biology calls the targets: combining RNAi and disease biology. October 15, 2005 van Es HH, Arts GJ. PubMed Target-based drug discovery starts with the identification of target genes and their re

Breakthrough for systemic RNAi May 15, 2006 Katherine Whalley drug discovery@nature.com RNA interference (RNAi) has become a powerful research tool, yet progress in developing therapeutic applic

Calando Formally Names Cancer as First Pipeline Program; Inks IP Licensing Deal with Alnylam By Doug Macron September 7, 2006 RNAi News Calando?s decision to pursue oncology comes as no surpris

Calando Presents Data on Cancer Drug Candidate In Monkeys, Reaffirms Timeline for Human Trial October 26, 2006 By Doug Macron RNAi News Calando CSO Jeremy Heidel presented data demonstrating th

Ciphergen Gets Ready to Bring Its Ovarian Cancer IVD to US, Europe By Tony Fong December 21, 2006 ProteoMonitor For a company recently transformed from a proteomics tool outfit into a diagnosti

Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery. May 2006 Constan?a Figueiredo, Axel Seltsam and Rainer Blasczyk Journal of Molecular Medicine Abstract HLA incom

Construction of plasmids for RNA interference and in vitro transcription of double-stranded RNA 2006 Timmons L. Methods Mol Biol. Double-stranded RNA (dsRNA)-induced gene silencing in Caenorhab

Court Rejects Protiva Motion to Dismiss Sirna Suit, OKs Request to Stay the Case By Doug Macron December 7, 2006 RNAi News Although the federal court rejected Protiva?s arguments that Sirna?s b

CytRx Successfully Completes Patient Dosing and Follow-Up in Phase IIa Clinical Trial for ALS; Plans to Announce Final Results in Early 4th Quarter July 24, 2006 CytRx (BusinessWire) LOS ANGELES-

Delivering on Promise of RNAi Therapeutics August 11, 2006 Carolyn Riley Chapman, PhD Drug Discovery and Development In 1998, scientists discovered that RNA not only acts as a simple intermedi

Delivering on Promise of RNAi Therapeutics August 11, 2006 Carolyn Riley Chapman, PhD Drug Discovery and Development n 1998, scientists discovered that RNA not only acts as a simple intermediary

Success is far from assured. Gene therapists have been trying to deliver naked DNA into cells for well over 25 years, with very limited success, says Mark Kay, director of the Program in Human Gene Th

Delivering RNA Interference November 13, 2006 Celia Henry Arnaud Chemical & Engineering News RNA interference is on the fast track. In the eight brief years since the RNAi gene-silencing mechani

Delivery methods for RNA interference in C. elegans 2006 Timmons L. Methods Mol Biol. This chapter describes four methods for delivery of double-stranded RNA to Caenorhabditis elegans (injectio

Delivery of RNA Interference 15 september 2006 Charles X Li, Amy Parker, Ellen Menocal, Shuanglin Xiang, Laura Borodyansky and Johannes H Fruehauf Landes Bioscience Over the last few years, RNA

To address these shortcomings, we tested a panel of molecular disruption agents to reduce secondary structure formation during chain elongation. Agents tested included; Q-solution (1?, Qiagen), betain

Design Rules for Dicer-Substrate RNAi 2005 Mark A. Behlke, M.D., Ph.D. Genetic Engineering News RNA interference is a biochemical process common to most eukaryotes where double-stranded RNA (dsR

Desperate for Cash, Benitec Pitches Share-Purchase Plan to Investors; Firm Needs $380K to Stay Afloat By Doug Macron August 3, 2006 RNAi News But even if it can secure the cash, the company sai

Dharmacon and Alcon to Collaborate on Discovery of Novel Eye Disease Therapies 10/25/2005 Genetic Engineering News Dharmacon, a business unit of the Fisher Biosciences group, agreed to collaborat

Dharmacon Partners with Lentigen to Develop, Market Lentiviral Reagents for shRNA Delivery By Doug Macron September 7, 2006 RNAi News For Dharmacon, the deal means the expansion of its product

Dissecting self-renewal in stem cells with RNA interference 11 June 2006 Natalia Ivanova, Radu Dobrin, Rong Lu, Iulia Kotenko, John Levorse, Christina DeCoste, Xenia Schafer, Yi Lun and Ihor R. Le

Drug Discovery: Clearing the Target Validation Bottleneck March 1, 2006 Kate Marusina, Ph.D. Genetic Engineering News The target validation step of the drug discovery process aims to prove that

Drug Discovery: In vivo and In vitro Techniques Help to Unclog the Drug Discovery Process Mar 1 2006 Genetic Engineering News The human genome has generated hundreds of potential new drug target

Drug Discovery: Target Identification Methods Advance February 15, 2006 Elizabeth Lipp Genetic Engineering News Spring is coming, and GENs thoughts have turned to target identification and the I

Engineer joins fight against Alzheimer's, diabetes December 8, 2006 MSU Today Christina Chan is using metabolic engineering and systems biology in the fight against Alzheimer?s disease and diabet

Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti March 14, 2006 Alexander W. E. Franz, Irma Sanchez-Vargas, Zach N. Adelman, Carol D. Blai

Fire and Mello win Nobel Prize 2nd October 2006 By Kerry Grens The Scientist Andrew Z. Fire, a professor in Stanford University School of Medicine's Department of Pathology and Genetics, and Cr

For Sirna, Talks on Drug-Development Deal Turn Into $1.1B Bet by Merck By Doug Macron November 2, 2006 RNAi News ?We had no intention of selling the company,? according to a Sirna official. But

GE to Abandon Printed CodeLink Arrays In '07 as Prospects for Growth 'Fall Short' By Justin Petrone December 19, 2006 BioArray News The decision to scuttle CodeLink came at a time when the arra

Gene Silencing Directs Muscle-Derived Stem Cells To Become Bone-Forming Cells June 2, 2006 Bioresearch Online Baltimore - Using a relatively new technology called RNA interference to turn off gen

Gene silencing fights mad cow disease December 1, 2006 Roxanne Khamsi New Scientist.com Silencing the genes that produce prion proteins can dramatically slow the progression of mad cow disease,

Gene Therapy Applications Of RNA Interference, Presented At The ASGT 9th Annual Meeting 03 Jun 2006 Medical News Today A study demonstrating one of the first therapeutic applications to exploit

Genome-wide screening for gene function using RNAi in mammalian cells June 2005 Lara M Cullen and Greg M Arndt Immunology and Cell Biology Summary Mammalian genome sequencing has identified numero

Genta Sinks to Q2 Loss After Sanofi Ends Alliance, Sees Life Left in Genasense as FDA Review Looms By Doug Macron August 10, 2006 RNAi News Though Genta was hurt after Sanofi-Aventis withdrew f

Glioblastomas display angiogenesis reduction upon telomerase inhibition May. 29, 2006 Clinical Oncology Week Therapeutics Daily Glioblastomas (GBMs) display angiogenesis reduction upon telomera

Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense July 2006 Ang?lique Deleris, Javier Gallego-Bartolome, Jinsong Bao, Kristin D. Kasschau, James C. Carrington, O

High Demand for Target Validation Technologies June 15, 2005 Usha Sankar, Ph.D. Genetic Engineering News The various methods used in target validation were the focus of discussion earlier this

Huntington?s disease meets its match June 6, 2006 Peter Aldhous New Scientist Huntington?s disease may be about to meet its match with the development of a therapy designed to knock out product

In ovo RNAi opens new possibilities for temporal and spatial control of gene silencing during development of the vertebrate nervous system February 2006 Thomas Baeriswyl and Esther T Stoeckli Jou

In vitro display technologies reveal novel biopharmaceutics 2006 Achim Rothe, Ralf J. Hosse and Barbara E. Power The FASEB Journal Display technologies are fundamental to the isolation of specific

In Vivo RNAi Silencing Juy 17, 2006 Carolyn Riley Chapman, PhD Drug Discovery & Development The use of RNAi as a research tool for target identification and validation, though relatively new,

Inclusion of a matrix-attached region in a 7SK pol III vector increases the efficiency of shRNA-mediated gene silencing in embryonic carcinoma cells January 24, 2006 Vihra N. Sotirova, Margaret A.

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors June 5, 2006 Laurent Boyer, Anne Doye, Monica Rolando, Gilles Flatau, Patrick M

Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans February 17, 2006 ROSALIND C. LEE, CHRISTOPHER M. HAMMELL and VICTOR AMBROS RNA C. elegans contains numerous small R

Interaction of viruses with the mammalian RNA interference pathway January 5, 2006 Sylvia Sch?tz and Peter Sarnow Science Direct Abstract It has been known for some time that plants and insects

Interfering RNA Silences Genes In 'slippery' Immune Cells 13 May 2006 Medical News Today A technical advance in laboratory techniques may provide biology researchers broader access to RNA interfe

Dr. Fitzgerald also says addition of RNAi technology has helped uncover ?several important mechanisms and target proteins for compounds that, while they had unique therapeutic activities in animal mod

International scientists present the latest advances in RNAi and its clinical impact 4-Dec-2006 EurekAlert The topic of this conference won the Nobel Prize in Medicine and Physiology this year

Isis Reports Phase II Data Showing Antisense Rx Cuts Cholesterol Regardless of Statin Use By Doug Macron November 16, 2006 RNAi News Shares of Isis climbed more than 20 percent after data showe

Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo March 2006 Li-fang GAO, Lian-ji Wen, Hao YU, Ling ZHANG, Yan MENG, Yue-ting SHAO, De-qi XU, Xue-jian ZHAO Blac

Knocking down transport: applications of RNA interference in the study of drug transport proteins. 2005 Tian X, Zhang P, Zamek-Gliszczynski MJ, Brouwer KL. PubMed RNA interference (RNAi) is a g

Lentigen and Dharmacon Pen shRNA Development Deal August 30, 2006 GenomeWeb NEW YORK (GenomeWeb News) ? Lentigen and Dharmacon today said they plan to develop and manufacture lentiviral expressio

Lentigen Corporation and the United States Army Enter Into a Cooperative Research and Development Agreement May 30, 2006 Lentigen Corporation BALTIMORE and EDGEWOOD, Md., May 30, 2006 /PRNewswire/

Lilly Tells Investors That Antisense Will Help Fuel Growth; RNAi Falls to the Wayside By Doug Macron RNAi News December 14, 2006 Although Lilly was an early mover in the RNAi space, striking a

Long-term RNAi can be deadly 25th May 2006 By Charles W. Choi The Scientist Long-term use of RNA interference (RNAi) can be fatal in mice, scientists report in this week's Nature. However, some

Thirdly, we tested whether inactivation of lin-35 increases gene silencing resulting from expression of an endogenously transcribed dsRNA. To do this, we took advantage of a system in which worms expr

Luminex Gears Up to Introduce Its First microRNA Products Through Co-Development Deal with Exiqon By Doug Macron September 21, 2006 RNAi News The deal calls for the companies to join Exiqon?s L

Manipulating and enhancing the RNAi response February 2006 Peter I Joyce, Joseph M Gallagher and Patricia E Kuwabara Journal of RNAi and Gene Silencing ABSTRACT The phenomenon that is known as

Market Unfamiliarity Prompts Mirus to Debut Veteran RNAi Gene-Function Tool as New September 28, 2006 By Doug Macron RNAi News Although the company touted its hydrodynamic delivery method as a ?

Mice deaths cast doubt on new gene test May 26, 2006 newKerala.com SANFORD, Calif: The deaths of a large number of mice involved in U.S. testing of a technique for inactivating genes has reported

Mice testicles reveal new class of RNAs 4 June 2006; Erica Cheek newsatnature.com Time to revise biology textbooks once again: scientists have discovered a new class of small RNAs lurking in mou

Millipore Releases AdenoSilence Vectors for RNAi Delivery December 4, 2006 PharmaLive BILLERICA, Mass., Dec. 4, 2006 --- Millipore Corporation today announced the launch of the first round of adeno

Molecular mechanisms of RNAi: Implications for development and disease 18 Apr 2005 Meenakshi Rao, Shanthini Sockanathan Birth Defects Research Part C: Embryo Today: Reviews Abstract Research ove

In addition to RANTES and its derivatives, the chemokine ligands macrophage inflammatory proteins 1alpha/beta (MIP-1alpha and MIP-1beta) also show an inhibiting effect by mediating a receptor blockade

Molecule Does More Than Slice And Dice RNA 1/13/2006 Bioresearch Online A team of Howard Hughes Medical Institute (HHMI) scientists has peeled back some of the mystery of how cells are able to tu

Nastech Breaks Out New RNAi Technologies, Evades Questions About Possible Deal for Dicer-Substrates By Doug Macron October 12, 2006 RNAi News At an analyst and institutional investor day, Naste

New RNAi Tools Enable Systematic Studies Of Gene Function 3/23/2006 Bioresearch Online Unique public-private partnership creates RNAi-based inhibitors for nearly every human and mouse gene, mak

NIH Issues Three RNAi-Related Grants, Announces Projects With RNAi Potential By Doug Macron December 14, 2006 RNAi News The grants include one involving the development of shRNA vectors to stud

Off-Target Effects Plague Drosophila RNAi September 11, 2006 By Jeffrey M. Perkel The Scientist Thousands of hits from dozens of genome-wide RNA interference screens in Drosophila cell cultures

Omics: Next-Generation RNA Interference Feb 15 2006 Stephanie Uder, Henry George, Betsy Boedeker Genetic Engineering News The technology of RNA interference has rapidly evolved as a revolutionar

Optimized Solutions for RNAi Experiments Oct 15 2005 Elizabeth Scanlan, Ph.D., Jorg Dennig, Ph.D., Ute Kruger, Ph.D., Tobias Bergauer, Ph.D., Silvia Magyar, Eric Lader, Ph.D. Genetic Engineering

OSU Study Links Two microRNAs With the Oncogene Responsible for B-Cell Leukemia December 21, 2006 By Doug Macron RNAi News According to the findings, which were published in Cancer Research, th

Patent for Seminal RNAi innovation Cleared in Australia July 22, 2006 MedIndia.com Opposition in Australia to the grant of patent application to the Carnegie Institution of Washington in relation

Preclinical Data from Isis, UCSD Shows Antisense Infusion Effective for ALS; Phase I Hinges on Cash By Doug Macron July 27, 2006 RNAi News Based on the findings, Isis said it remains committed

Preparing for a Potential Pandemic September 1, 2005 Gail Dutton Genetic Engineering News As the influenza season approaches, health officials remain concerned about the H5N1 strain of avian flu

Proceed With Care May 25, 2006 Celia Henry Arnaud Chemical and Engineering News A new study sounds a cautionary note for one form of RNA interference (RNAi). Researchers at Stanford University

Protiva Seeks to Dismiss Sirna Suit Because US Unit Not Named; Says Sirna Offers No Evidence By Doug Macron September 21, 2006 RNAi News Protiva's plan to ask for a dismissal of the Sirna lawsu

Quark Becomes Latest RNAi Drug Developer To Score Big Pharma Support With Pfizer Deal By Doug Macron September 28, 2006 RNAi News Under the deal, Pfizer has acquired an exclusive license to RTP

Quark Licenses Alnylam RNAi IP, Vows to End Opposition to IP in Europe, and Pens Deal With Pfizer September 27, 2006 Genome Web Daily News NEW YORK (GenomeWeb News) ? Alnylam Pharmaceuticals has

RAC Committee Raises Issues With Nucleonics' HBV Trial; Firm Says IND Timeline Unchanged December 21, 2006 By Doug Macron RNAi News Earlier this month, the NIH?s Recombinant DNA Advisory Commit

Researchers Aim to Sequence Small RNAs in Plants Algae Using Solexa's New Sequencing Technology By Doug Macron October 5, 2006 RNAi News The project will incorporate Solexa?s soon-to-be release

Responding to Suit, Open Biosystems Denies It Infringed IP; Countersues Sigma, Oxford BioMedica By Doug Macron August 3, 2006 RNAi News Since the beginning of the legal dispute, Open Biosystems

Reverse genetics for proteomics: From proteomic discovery to scientific content July 12, 2006 M. Bauer and M. Ueffing Springerlink Summary. Proteomic strategies generally result in rather descr

RNA interference (RNAi) is coming of age as a therapeutic modality May 09, 2006 PharmaLive With four clinical stage projects and 14 projects approaching IND status within the next year, RNAi is

RNA interference as potential therapy for neurodegenerative disease December 16, 2005 Henry Paulson, MD, PhD Neurology The discovery of RNA interference (RNAi) has led to powerful new approache

RNA Interference as the New Gene Therapy May 25, 2006 FightAging.org It's easy to draw parallels between work on RNA interference (RNAi) today and gene therapy circa 1986. Both have demonstrated

RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila April 2006 Xiao-Hong Wang,Roghiyh Aliyari,Wan-Xiang Li, Hong-Wei Li, Kevin Kim, Richard Carthew, Peter Atkinson, Shou-W

RNA interference for antiviral therapy 2006 Aug Ketzinel-Gilad M, Shaul Y, Galun E. J Gene Med. Silencing gene expression through a process known as RNA interference (RNAi) has been known in th

RNA Interference Gene Therapy Takes Two Steps Forward, One Step Back May 30, 2006 Haber Saglik Three years ago Mark Kay, MD, PhD, published the first results showing that a hot new biological ph

RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy 2006 Sep Santel A, Aleku M, Keil O, Endruschat J, Esche V, Durieux B, Loffler K

RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System 2006 Jul 7 Howard KA, Rahbek UL, Liu X, Damgaard CK, Glud SZ, Andersen MO, Hovgaard MB, Schmitz A, Nyengaard

RNA interference passes a big test June 7, 2006 Eric Berger SciGuy You may never have heard of it before, but a technique called RNA interference, or RNAi, has been all the rage in biology labs

RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon--primed macrophages December 2005 Jean-Fr?d?ric Flandin, Fr?d?ric Chano, Alb

RNA interference screens are questioned September 12, 2006 DailyIndia.com SANFORD, Calif., Sept. 12 (UPI)-U.S. geneticists say many genes identified as targets of RNA interference, or RNAi, in th

RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts 2006 Jul Grzelinski

RNA Interference: Film at Eleven October 2, 2006 Derek Love Corante Every time a Nobel Prize is announced, reporters try to put in some sort of "news you can use" context. That's usually pretty ea

RNA interference: Natural, experimental, and clinical roles in cancer biology 2006 Jul 5 Mroz EA, Rocco JW. Head Neck. The old idea of using antisense RNA to block messenger RNA has recently l

RNA interference: Targeted delivery by an RNA double August 2006) by Charlotte Harrison Nature Reviews: Drug Delivery One of the major hurdles facing the development and therapeutic application

RNA therapy tackles eye disease June 6, 2006 Jacqueline Ruttimann news@nature.com The commonest cause of blindness in the elderly has been treated with small pieces of genetic material that bloc

RNA-Interference Effectors and Their Delivery 2006 Putnam D, Doody A. Crit Rev Ther Drug Carrier Syst. RNA-interference, the mechanism by which the expression of a specific protein can be reduc

RNAi and cancer: Implications and applications February 2006 Maen Abdelrahim , Stephen Safe, Cheryl Baker and Ala Abudayyeh Journal of RNAi and Gene Silencing ABSTRACT RNA interference (RNAi) is

RNAi Community Expected Fire and Mello to Win Nobel Prize, But Not Necessarily So Soon By Doug Macron October 5, 2006 RNAi News Despite being the most important recognition of the gene-silencin

RNAi Outsider Senetek Looking for Pharma Partner to Develop, Sell Its Brain Cancer Rx By Doug Macron November 30, 2006 RNAi News Armed with an in-licensed RNAi-based brain cancer drug, Senetek

RNAi technology: a revolutionary tool for the colorectal cancer therapeutics 2006 Aug 7 Lv W, Zhang C, Hao J. World J Gastroenterol. With the many changes that have taken place in people's diet

The extraordinary selectivity of RNAi, combined with its potency?in theory, only a few dsRNAs are needed per cell?quickly made it the tool of choice for functional genomics (determining what a gene pr

RNAi's Competence as a Drug Discovery Technology Promotes use of RNAi Content and Delivery, Screening, and Analysis Tools 2006 HT Screening.net Ribonucleic acid interference delivery remains one

Early on, researchers assumed that a single RNAi knocked down a single gene causing a phenotype. "What we know now is that single siRNA was probably affecting tens if not hundreds of genes," says Davi

RNAi, DRD1, and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation June 6, 2006 Simon W.-L. Chan,, Ian R. Henderson, Xiaoyu Zhang, Govind Shah, Jason S.-C. Chien,

RNAi-based knockdown of HBx mRNA in HBx-transformed and HBV-producing human liver cells 2006 Jul Kim YH, Lee JH, Paik NW, Rho HM. DNA Cell Biol. RNA interference (RNAi) is the process of sequen

RNAi-based suppression and replacement of rds-peripherin in retinal organotypic culture 17 Jan 2006 Arpad Palfi, Marius Ader, Anna-Sophia Kiang, Sophia Millington-Ward, Gerry Clark, Mary O'Reill

RNAi-mediated gene silencing in non-human primates Engineering Village 2 2006 Elsevier Inc. Accession number: 063110042585 Title: RNAi-mediated gene silencing in non-human primates

RNAi-mediated silencing of estrogen receptor in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors June 27, 2006 Sergei Musatov, Walter Chen, Donald W. Pfaff, Michael G. K

RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells 26 January 2006 Gregory Cesarone , Cecilia Garofalo , Marc T. Abram

RNAi: A novel antisense technology and its therapeutic potential APR 2006 Dallas A, Vlassov AV MEDICAL SCIENCE MONITOR 12 Abstract: Antisense oligonucleotide agents induce the inhibition of ta

RNAi: for functional analysis and target validation. April 2006 Rondinone CM. PubMed he third annual conference on discovery on target, organised by the Cambridge Healthtech Institute was held o

Rosetta Files to Float 3.45M Shares on Nasdaq; Israeli microRNA Firm Could Net $37.1M in IPO By Doug Macron September 7, 2006 RNAi News Should the IPO go forward, Rosetta Genomics would become

Roundworms used in cancer research December 6, 2006 By Anna Faltermeier Kansan.com KU researchers are making discoveries about the role of genetics in cancer by researching tiny roundworms, abou

SAK, A New Polo-Like Kinase, Is Transcriptionally Repressed by p53 and Induces Apoptosis upon RNAi Silencing April 2005 Li, Jun; Tan, Mingjia; Li, Ling; Pamarthy, Deepika; Lawrence, Theodore S.; Su

Sigma-Aldrich and Oxford BioMedica File Suit Against Open Biosystems June 14, 2006 RNAI.net Sigma-Aldrich and Oxford BioMedica have announced that they have filed a lawsuit against Open Biosystem

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model 13 March 2005 Scott Ralph, Pippa A Radcliffe, Denise M Day, Janine M Carthy, Marie A Lerou

Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes 2006 Jul 25 Henry SD, van der Wegen P, Metsela

Sirna Battles Genes Gone Bad Aug. 15, 2006 By Ralph Casale MSNBC Sirna Therapeutics (Nasdaq: RNAI) is one of several companies hoping to shut down diseases and disorders at the genetic level. V

Sirna Q2 Losses Rise as Company Spends Ahead Of HCV Phase I Trial; Officials Give Study Details By Doug Macron August 17, 2006 RNAi News The majority of the company?s second-quarter expenses we

SR Pharma Establishes GMP Production with Partners for RNAi Therapeutic Product June 16, 2006 SR Pharma SR Pharma plc has announced that its operating subsidiary Atugen AG, has established collab

Startup Rational Affinity Takes Aim at MicroRNA Profiling Market With the Support of an NIH Grant By Doug Macron October 19, 2006 RNAi News The company, which was founded about a year ago to de

Study on mice suggests flaw in a gene therapy MAY 26, 2006 By Andrew Pollack International Herald Tribune NEW YORK: A large number of mice died unexpectedly in a test of a new technique for ina

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. February 2005 Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ. PubMed RNA interference (RNAi) is the process of sequenc

The Crowded Field of VEGF and VEGF-R Targeting Drugs August 17, 2006 La Merie Barcelona, Spain, August 17, 2006 --(PR.COM)-- The Business Intelligence firm La Merie S.L. reported today that the ver

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing 23 July 2006 Maria-Carla Saleh, Ronald P. van Rij, Armin Hekele, Amethyst Gillis, Edan Foley, Patrick H. O'Farrell& Raul

The Nonviral Episomal Replicating Vector pEPI-1 Allows Long-Term Inhibition of bcr-abl Expression by shRNA Apr 2005 Andreas C.W. Jenke, Tobias Eisenberger, Armin Baiker, Isa M. Stehle, Stefan Wirt

The Therapeutic Potential of RNAi October 2, 2006 By Emily Singer Technology Review One of the biggest scientific advances of the last decade has been RNA interference: a natural process used by o

Therapeutic potential of RNA interference against cancer 2006 Aug Takeshita F, Ochiya T. Cancer Sci. One of the most dramatic events of the past 5 years in the field of molecular biology has b

Therapies for HIV with RNAi. February 2006 Nekhai S, Jerebtsova M. PubMed RNA interference (RNAi) is a process in which double-stranded RNA triggers the silencing of gene expression in a sequenc

Thermodynamics of RNA?RNA binding January 29, 2006 Ulrike M?ckstein, Hakim Tafer, J?rg Hackerm?ller, Stephan H. Bernhart, Peter F. Stadler and Ivo L. Hofacke Bioinformatics Background: Reliable pr

Three Sirna Shareholders Sue to Block Merck Acquisition; Sirna Posts Higher Q3 Losses By Doug Macron November 16, 2006 RNAi News Sirna said the lawsuits, which are seeking class-action status, a

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis November 28, 2005 Manjeet K. Rao, John Pham, J. Saadi Imam, James A. MacLean, Deepa

Quark Becomes Latest RNAi Drug Developer To Score Big Pharma Support With Pfizer Deal September 28, 2006 by Doug Macron RNAi News Under the deal, Pfizer has acquired an exclusive license to RTP-80

Tool to silence genes in specific tissues using RNAi developed August 18, 2006 Medicine News. net Reporting in the journal Genes and Development, investigators at The University of Texas M. D. An

Transposon-based RNAi delivery system for generating knockdown cell lines April 9, 2004 Arnold D. Heggestad, Lucia Notterpek and Bradley S. Fletcher Biochemical and Biophysical Research Communic

Two Firms Receive NIH Grants in August To Support MicroRNA Tool Development By Doug Macron September 28, 2006 RNAi News One grant will help Mirus Bio develop a blood-based reporter system to al

University of Edinburgh Joins Sigma's RNAi Program October 3, 2006 Genome Web Daily News NEW YORK (GenomeWeb News) ? Sigma-Aldrich said yesterday that researchers at the University of Edinburgh hav

US Genomics and Lahey to Explore miRNA-based Urologic Cancer Biomarkers for Dx Development By Doug Macron October 26, 2006 RNAi News The deal, US Genomics? second involving miRNA-based diagnost

Using Nature's Primitive Anti-Viral Defense System to Find Approaches to Cancer Research September 14, 2006 GenomicsProteonics.com The humble fruit fly and a grant from the AICR (the Association