Patent Articles - Lyophilization

 European Patents - Lyophilization
 Patent Pending - Lyophilization
Activation of enzymes by lyophilization in the presence of solid inorganic support
Activation of enzymes by lyophilization in the presence of solid inorganic support Inventor: PFROMM PETER (US); WUERGES KERSTIN (DE) IPC: C12N9/00; C12N9/00 Publication info: US2006183208 Date:
Amorphous nitric esters and their pharmaceutical compositions
Amorphous nitric esters and their pharmaceutical compositions EC: C07C203/04 IPC: A61K9/10; A61K9/14; A61K31/621 Publication info: RU2248963 Date: 2005-03-27 Abstract not available for RU2248
APPARATUS, SYSTEM AND METHOD FOR LYOPHILIZATION
APPARATUS, SYSTEM AND METHOD FOR LYOPHILIZATION Publication Number: WO/2005/073652 International Application No.: PCT/IL2005/000124 Publication Date: 11.08.2005 International Filing Date
Aqueous process for manufacturing paroxetine solid dispersions
Title: Aqueous process for manufacturing paroxetine solid dispersions United States Patent: 6,168,805 Inventors: Hein, II; William A. (Hasbrouck Heights, NJ); Chang; Sou-Chan (Westbury, NY); Kao
Automated Karl Fischer titration apparatus and method
United States Patent 5,340,541 Jackson , et al. August 23, 1994 Automated Karl Fischer titration apparatus and method Abstract Automation of the coulometric Karl Fischer titration has all
BIOLOGICAL MATERIAL AND METHODS AND SOLUTIONS FOR PRESERVATION THEREOF
BIOLOGICAL MATERIAL AND METHODS AND SOLUTIONS FOR PRESERVATION THEREOF Publication Number: WO/2005/072523 International Application No.: PCT/IL2005/000125 Publication Date: 11.08.2005 In
CALIBRATION VIAL STOPPER WITH IMPROVED SECURITY FEATURES
CALIBRATION VIAL STOPPER WITH IMPROVED SECURITY FEATURES Publication Number: WO/2006/066056 International Application No.: PCT/US2005/045531 Publication Date: 22.06.2006 International Fili
Clump-free liquid dispersible powder compositions and process for making the same
Title: Clump-free liquid dispersible powder compositions and process for making the same United States Patent: 6,361,799 Inventors: Palkhiwala; Burgise F. (East Windsor, NJ) Assignee: Accumed
Composition and method for stable injectable liquids
United States Patent 6,190,701 Roser , et al. February 20, 2001 Composition and method for stable injectable liquids Abstract A composition for delivering a stable, bioactive compound to
Composition, useful or cosmetic or medicinal purpose e.g. in the form of mask, comprises collagen (e.g. fish collagen) and carbohydrates (e.g. carboxymethyl cellulose)
Composition, useful or cosmetic or medicinal purpose e.g. in the form of mask, comprises collagen (e.g. fish collagen) and carbohydrates (e.g. carboxymethyl cellulose) Inventor: SCHAEFER GISBERT (D
Compositions and methods for nucleic acid delivery to the lung
Title: Compositions and methods for nucleic acid delivery to the lung United States Patent: 5,994,314 Inventors: Eljamal; Mohammed (San Jose, CA); Patton; John S. (San Carlos, CA); Foster; Linda
Container with freeze-dried vaccine components
Title: Container with freeze-dried vaccine components United States Patent: 6,106,836 Inventors: Wilderbeek; Antonius Theodorus Maria (Well, NL); Middelbeek; Hans Almer (Oss, NL) Assignee: Ak
Controlled release insufflation carrier for medicaments
Title: Controlled release insufflation carrier for medicaments United States Patent: 5,962,009 Inventors: Baichwal; Anand (Wappingers Falls, NY); Staniforth; John N. (Bath, GB) Assignee: Edwa
CRYO-PROTECTIVE AGENTS FOR MICROORGANISMS
CRYO-PROTECTIVE AGENTS FOR MICROORGANISMS Publication Number: WO/2005/054443 International Application No.: PCT/CA2004/002025 Publication Date: 16.06.2005 International Filing Date: 30.1
CRYOGENIC HEAT EXCHANGE SYSTEM AND FREEZE DRYER
(12) Patent: (11) CA 2117858 ABSTRACT: A cryogenic heat exchange system and freeze dryer incorporating the same. The cryogenic heat exchange system has a heat exchanger provided with at least
Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle
Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle Inventor: MIZUSHIMA YUTAKA (JP); OGAWA YASUAKI (JP) EC: A61K9/16H2; A6
DRUG/POLYMER COMPLEX, PREFERABLY CIPROFLOXACIN/HPMC, ITS METHOD OF MANUFACTURING USING LYOPHILIZATION AND ITS USE IN AN OSMOTIC DEVICE
DRUG/POLYMER COMPLEX, PREFERABLY CIPROFLOXACIN/HPMC, ITS METHOD OF MANUFACTURING USING LYOPHILIZATION AND ITS USE IN AN OSMOTIC DEVICE Publication Number: WO/2006/007354 International Applic
Drying apparatus and methods
Inventors: Savarese; Mark (Suite 4, NE. Hickman Ct., Pullman, WA 99163) Abstract: Apparatus and method for drying a product comprising placing the product on a first side of a support surface, and d
FIBRILLAR MICROSTRUCTURE AND METHODS FOR MAKING IT
FIBRILLAR MICROSTRUCTURE AND METHODS FOR MAKING IT Publication Number: WO/2006/029194 International Application No.: PCT/US2005/031831 Publication Date: 16.03.2006 International Filing D
Formulation solubilizing water-insoluble agents and preparation method thereof
514/559 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS Chalcogen attached indirectly to the 9- position of the purine ring system by acyclic nonionic bonding Radical -XH acid, or anhydride, ac
Free-flowing dry particles
Title: Free-flowing dry particles United States Patent: 6,030,645 Inventors: Tritsch; Jean-Claude (Saint-Louis, FR); Ulm; Johann (Oberwil, CH) Assignee: Roche Vitamins Inc. (Nutley, NJ) App
FREEZE DRIED BIOLOGICAL SPECIMENS
(12) Patent: (11) CA 1087101 Application Number: (21) 284215 ABSTRACT A method for preparing a naturally coloured and flexible freeze dried animal specimen for study or display purposes
FREEZE DRIED PHARMACEUTICALS
(12) Patent: (11) CA 1131245 Abstract of the Disclosure Process for preparing Aspirin salts having improved stability and compositions containing same. (72) Inventors (Country): SMITH, WAL
Freeze drying apparatus and method employing vapor flow monitoring and/or vacuum pressure control
United States Patent 6,122,836 Tenedini , et al. September 26, 2000 Freeze drying apparatus and method employing vapor flow monitoring and/or vacuum pressure control Abstract Freeze dryin
Freeze drying methods employing vapor flow monitoring and/or vacuum pressure control
United States Patent 6,226,887 Tenedini , et al. May 8, 2001 Freeze drying methods employing vapor flow monitoring and/or vacuum pressure control Abstract Freeze drying apparatus and asso
FREEZE DRYING WITH REDUCED CRYOGEN CONSUMPTION
(12) Patent: (11) CA 2282866 ABSTRACT: A method and apparatus for controlling the temperature of a freeze drying chamber shelves and chamber in a refrigeration system having a condenser operat
Freeze-drying microscope stage apparatus and process of using the same
Freeze-drying microscope stage apparatus and process of using the same Inventor: GYORY J R (US); GONZALEZ-ZUGASTI JAVIER (US) IPC: F26B5/06; C12Q1/00; F26B5/04 Publication info: US2006053652 Da
Ionically formulated biomolecule microcarriers
United States Patent 6,645,525 Woiszwillo November 11, 2003 Ionically formulated biomolecule microcarriers Abstract Compositions for sustained delivery of a biomolecule including an anionic
JOINT LYOPHILIZATION-MEDIATED FORMATION OF PEPTIDE-LIPID COMPLEX
JOINT LYOPHILIZATION-MEDIATED FORMATION OF PEPTIDE-LIPID COMPLEX Inventor: DASSEUX JEAN-LOUIS EC: A61K9/127M; A61K9/127P IPC: A61K9/19; A61K9/127; A61K38/00 Publication info: RU2224506 Date:
LIPOSOMAL-POLYENE PRELIPOSOMAL POWDER AND METHOD FOR ITS PREPARATION
(12) Patent: (11) CA 2099771 ABSTRACT: A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes
LYOPHILIZATION METHOD TO IMPROVE EXCIPIENT CRYSTALLIZATION
LYOPHILIZATION METHOD TO IMPROVE EXCIPIENT CRYSTALLIZATION Inventor: JUNEAU JENNIFER (US); KNOWLES SUSAN (US) Applicant: WYETH CORP (US); JUNEAU JENNIFER (US) EC: A61K9/19 IPC: A61K9/00; A61K
Lyophilization of bulk pharmaceuticals
United States Patent 5,031,336 Diesner , et al. July 16, 1991 Lyophilization of bulk pharmaceuticals Abstract A process for lyophilizing bulk solutions of products in which liquid product
LYOPHILIZATION OF VIROSOMES
LYOPHILIZATION OF VIROSOMES Publication Number: WO/2006/069719 International Application No.: PCT/EP2005/013829 Publication Date: 06.07.2006 International Filing Date: 21.12.2005 In
LYOPHILIZED NATIVE GAMMA GLOBULIN PREPARATION FOR INTRAVENOUS ADMINISTRATION
(12) Patent: (11) CA 1093965 Application Number: (21) 304887 ABSTRACT: 18/12 LYOPHILIZED NATIVE GAMMA GLOBULIN PREPARATION FOR INTRAVENOUS ADMINISTRATION ABSTRACT OF THE DISCLOSUR
LYOPHILIZED OR PRECIPITATED CEPHALOSPORIN ZWITTERION AND SALT COMPOSITION
(12) Patent: (11) CA 1307464 Application Number: (21) 551105 ABSTRACT: ABSTRACT OF THE DISCLOSURE Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solutio
LYOPHILIZED PHARMACEUTICAL PREPARATIONS CAPABLE OF PROVIDING AQUEOUS DRUG COMPOSITION HAVING PROPERTY OF REVERSIBLE THERMOSETTING GELATION
(12) Patent: (11) CA 2202520 ABSTRACT: Herein disclosed is a lyophilized pharmaceutical preparation obtained by lyophilizing an aqueous composition having property of reversible thermosetting
Medical powder
Title: Medical powder United States Patent: 6,162,469 Inventors: Atarashi; Takafumi (Tokyo, JP); Nakatsuka; Katsuto (Miyagi, JP) Assignee: Nittetsu Mining Co., Ltd. (Tokyo, JP); Katsuta Nakat
Method for drying microspheres
Title: Method for drying microspheres United States Patent: 6,080,429 Inventors: Cleland; Jeffrey L. (San Carlos, CA); Jones; Andrew J. S. (San Mateo, CA); Powell; Michael Frank (San Francisco,
METHOD FOR IMPROVING STABILITY AND SHELF-LIFE OF LIPOSOME COMPLEXES
METHOD FOR IMPROVING STABILITY AND SHELF-LIFE OF LIPOSOME COMPLEXES Publication Number: WO/2005/000271 International Application No.: PCT/US2004/017695 Publication Date: 06.01.2005 Inter
Method for lyophilizing an active agent
Method for lyophilizing an active agent United States Patent 6,907,679 Yarborough , et al. June 21, 2005 Inventors: Yarborough; Cody L. (Ft. Collins, CO), Madril; Dominic G. (Loveland,
Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
436/535 CHEMISTRY: ANALYTICAL AND IMMUNOLOGICAL TESTING INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS Carrier is organic Antigen or antibody entrapped within the carrier (e.g.,
Method for producing powder formulation comprising an insulin
Title: Method for producing powder formulation comprising an insulin United States Patent: 6,043,214 Inventors: Jensen; Steen (Drag.o slashed.r, DK); Hansen; Philip (Holte, DK). Assignee: Nov
METHOD FOR PRODUCING THE MICROCAPSULATED FORM OF A LIVE VIRAL VACCINE
METHOD FOR PRODUCING THE MICROCAPSULATED FORM OF A LIVE VIRAL VACCINE Inventor: SANDAKHCHIEV LEV STEPANOVICH (RU); NECHAEVA ELENA AVGUSTOVNA (RU) Applicant: G NAUCHNY TS VIRUSOLOGII I BIO (RU); SA
Method of dehydrating vesicle preparations for long term storage
United States Patent 5,089,181 Hauser February 18, 1992 Method of dehydrating vesicle preparations for long term storage Abstract In the presence of a preserving additive, unilamellar phosp
Method of manufacturing powder particles
Title: Method of manufacturing powder particles United States Patent: 6,479,077 Issued: November 12, 2002 Inventors: Borra; Jean-Pascal Dominique M (Chanteloup, FR) Assignee: Technische U
METHOD OF PACKAGING FREEZED DRIED VACCINES IN SYRINGES AND PLUG FOR IMPLEMENTING THE METHOD
(12) Patent: (11) CA 2061204 ABSTRACT In a method of packaging freeze dried vaccine in a bypass syringe (1) the sterilized syringes are disposed in rows in an aseptic dispensing machine. Doses (
Method of preparing a freeze-dried formulation containing a drug
United States Patent 5,044,091 Ueda , et al. September 3, 1991 Method of preparing a freeze-dried formulation containing a drug Abstract In a freeze-drying method for producing a dried ph
Method of preserving lyophilized microorganisms for transport, storage and recovery of viable microorganisms
Method of preserving lyophilized microorganisms for transport, storage and recovery of viable microorganisms Inventor: GIBSON CECIL (US); CHRISOPE GERALD (US) IPC: A61K35/12; A01N1/02; A61K35/12
Method of producing a solid dispersion of a poorly water soluble drug
Title: Method of producing a solid dispersion of a poorly water soluble drug United States Patent: 5,985,326 Inventors: Butler; James Matthew (Romford, GB) Assignee: ICOS Corporation (Bothel
METHODS TO PRODUCE LUNG SURFACTANT FORMULATIONS VIA LYOPHILIZATION AND FORMULATIONS AND USES THEREOF
METHODS TO PRODUCE LUNG SURFACTANT FORMULATIONS VIA LYOPHILIZATION AND FORMULATIONS AND USES THEREOF Publication Number: WO/2006/055532 International Application No.: PCT/US2005/041281 P
Multi-functional container closure delivery system
Multi-functional container closure delivery system Inventor: CHANG BYEONG S (US); LIU ROGER W (US) IPC: B67D5/60; B67D5/60 Publication info: US2006157507 Date: 2006-07-20 Abstract of US200615
Ni catalysts and methods for alkane dehydrogenation
Ni catalysts and methods for alkane dehydrogenation United States Patent 7,227,049 Liu June 5, 2007 Inventors: Liu; Yumin (San Jose, CA) Assignee: Celanese International Corporation (Dal
NON-ANIMAL ORIGIN STABILIZERS AND PROCESSES FOR PRODUCING THE SAME
NON-ANIMAL ORIGIN STABILIZERS AND PROCESSES FOR PRODUCING THE SAME Publication Number: WO/2005/071067 International Application No.: PCT/US2005/000359 Publication Date: 04.08.2005 Intern
ORAL DELIVERY SYSTEMS COMPRISING A DRUG/POLYMER COMPLEX
ORAL DELIVERY SYSTEMS COMPRISING A DRUG/POLYMER COMPLEX Inventor: DONG LIANG CHANG (US); HAN JASMINE E (US) Applicant: ALZA CORP (US); DONG LIANG CHANG (US) EC: A61K9/19 IPC: A61K9/00; A61K9/00
Particle delivery techniques
Title: Particle delivery techniques United States Patent: 6,893,664 Issued: May 17, 2005 Inventors: Burkoth; Terry Lee (Palo Alto, CA); Sarphie; David Francis (Madison, WI); Muddle; Andrew G
Pharmaceutical compositions comprising rafamycin coprecipitates
Title: Pharmaceutical compositions comprising rafamycin coprecipitates United States Patent: 6,004,973 Inventors: Guitard; Patrice (Hegenheim, FR); Haeberlin; Barbara (Riehen, CH); Link; Rainer
PHARMACEUTICAL FORMULATION AND PROCESS
PHARMACEUTICAL FORMULATION AND PROCESS Inventor: KRISHNAMURTHY RAJESH (US); SURYANARAYANAN RAJ (US) Applicant: HUMAN GENOME SCIENCES INC (US); KRISHNAMURTHY RAJESH (US) IPC: A61K39/00; A61K39/00
Powder Composition for nasal administration
Title: Powder Composition for nasal administration United States Patent: 6,835,389 Issued: December 28, 2004 Inventors: Dohi; Masahiko (Hino, JP); Uejima; Yasuhide (Hino, JP); Fujii; Takao (
Powder compositions
Title: Powder compositions United States Patent: 6,048,549 Inventors: Nitikhunkasem; Attaya (Bangkok, TH); Khaiat; Alain V. (Singapore, SG); Hopkins; John (Newbury, GB) Assignee: Johnson & Jo
Powder formation by atmospheric spray-freeze drying
Powder formation by atmospheric spray-freeze drying FreePatentsOnline.com Inventors:Wang, Zhaolin (Edmonton, CA, US) Finlay, Warren H. (Edmonton, CA, US) Application Number:318864 Filing Date:12
Powdered pharmaceutical formulations having improved dispersibility
Title: Powdered pharmaceutical formulations having improved dispersibility United States Patent: 6,136,346 Inventors: Eljamal; Mohammad (Tripoli, LB); Patton; John S. (San Carlos, CA); Foster; L
Powders for inhalation
Title: Powders for inhalation United States Patent: 6,045,828 Inventors: Bystrom; Katarina (Genarp, SE); Nilsson; Per-Gunnar (Malmo, SE) Assignee: Astra Aktiebolag (SE) Appl. No.: 617918
PROCESS AND CONTAINER FOR FREEZE DRYING UNDER STERILE CONDITIONS
(12) Patent: (11) CA 1337974 Application Number: (21) 600212 ABSTRACT: The present invention provides a process for freeze drying of especially biologically or pharmaceutical material
PROCESS FOR FREEZE DRYING CYCLOPHOSPHAMIDE
(12) Patent: (11) CA 1215649 Application Number: (21) 457672 ABSTRACT: PROCESS FOR FREEZE DRYING CYCLOPHOSPHAMIDE ABSTRACT OF THE DISCLOSURE A two-stage process for freeze-drying an
Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid Inventor: KUMAR ASHOK (US); SOUDAGAR SATISH R (US) IPC: A61K31
PROCESS FOR PRODUCING SMALL PARTICLES OF BIOLOGICALLY ACTIVE MOLECULES
12) Patent: (11) CA 2030551 ABSTRACT: Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified g
PROCESS FOR PRODUCING STABLE MACROMOMYCIN POWDER
(12) Patent: (11) CA 1057659 Application Number: (21) 245488 ABSTRACT: PROCESS FOR PRODUCING STABLE MACROMOMYCIN POWDER ABSTRACT There is provided a process for producing a stable macro
Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions
Title: Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions United States Patent: 6,027,747 Inventors: Terracol; Didier (4 allee des Lauriers
PROCESS TO OBTAIN EXTRACTS, FRACTIONS AND ISOLATED COMPOUNDS FROM COPAIFER SPECIES AND THEIR USE FOR THE TREATMENT OF URINARY LITHIASIS IN HUMAN BEINGS AND ANIMALS
PROCESS TO OBTAIN EXTRACTS, FRACTIONS AND ISOLATED COMPOUNDS FROM COPAIFER SPECIES AND THEIR USE FOR THE TREATMENT OF URINARY LITHIASIS IN HUMAN BEINGS AND ANIMALS Publication Number: WO/2005/11
Single-use syringe
United States Patent Application 20030014017 Kind Code A1 Hatch, Thomas January 16, 2003 Single-use syringe Abstract Disclosed is a single-use syringe comprising a needle housing, a bore
Solid dispersion composition
Title: Solid dispersion composition United States Patent: 6,753,330 Issued: June 22, 2004 Inventors: Takano; Niichiro (Fuji, JP); Kawashima; Hiroyuki (Fuji, JP); Shinoda; Yasuo (Shizuoka, JP
Solid pharmaceutical dispersions
Title: Solid pharmaceutical dispersions United States Patent: 6,677,362 Issued: January 13, 2004 Inventors: Ghebre-Sellassie; Isaac (Morris Plains, NJ); Reisch, Jr.; Robert (Butler, NJ); Par
Solid solution beadlet
Title: Solid solution beadlet United States Patent: 6,692,767 Issued: February 17, 2004 Inventors: Burnside; Beth A. (Silver Spring, MD); McGuinness; Charlotte M. (Bethesda, MD); Rudnic; Edw
Solid solution of an antifungal agent with enhanced bioavailability
Title: Solid solution of an antifungal agent with enhanced bioavailability United States Patent: 5,972,381 Inventors: Sangekar; Surendra A. (Union, NJ); Lee; Ping I. (Radnor, PA); Vadino; Winsto
Spray drying of macromolecules to produce inhaleable dry powders
Title: Spray drying of macromolecules to produce inhaleable dry powders United States Patent: 6,582,728 Issued: June 24, 2003 Inventors: Platz; Robert M. (Half Moon Bay, CA); Patton; John S.
STABILIZATION OF ALUM-ADJUVANTED IMMUNOLOGICALLY ACTIVE AGENTS
STABILIZATION OF ALUM-ADJUVANTED IMMUNOLOGICALLY ACTIVE AGENTS Inventor: MAA YUH-FUN (US); SELLERS SCOTT (US) Applicant: ALZA CORP (US) EC: A61K9/16H6F; A61K9/70 IPC: A61K9/19; A61K39/39; A61K
STABLE LYOPHILIZED LIVE HERPES VIRUS VACCINE
(12) Patent: (11) CA 1324956 Application Number: (21) 565792 ABSTRACT: TITLE OF THE INVENTION A STABLE LYOPHILIZED LIVE HERPES VIRUS VACCINE ABSTRACT OF THE INVENTION The inventio
STANDARD ITEM FOR FRACTIONAL DETERMINATION OF COMPONENT OF LIPOPROTEIN
STANDARD ITEM FOR FRACTIONAL DETERMINATION OF COMPONENT OF LIPOPROTEIN Publication Number: WO/2006/054519 International Application No.: PCT/JP2005/020845 Publication Date: 26.05.2006 In
Storage stable powder compositions of interleukin-4 receptor
Title: Storage stable powder compositions of interleukin-4 receptor United States Patent: 6,896,906 Issued: May 24, 2005 Inventors: Hastedt; Jayne E. (San Carlos, CA); Cabot; Kirsten M. (San
SUPPORT SYSTEM FOR FLEXIBLE LYOPHILIZATION CONTAINERS
SUPPORT SYSTEM FOR FLEXIBLE LYOPHILIZATION CONTAINERS Publication Number: WO/2006/028648 International Application No.: PCT/US2005/028619 Publication Date: 16.03.2006 International Filin
ULTRA-FINE PHOSPHORS COATED WITH DOPED NANOSTRUCTURED OXIDES
ULTRA-FINE PHOSPHORS COATED WITH DOPED NANOSTRUCTURED OXIDES Publication Number: WO/2005/116162 International Application No.: PCT/FR2005/001174 Publication Date: 08.12.2005 Internationa
UV FILTERS IN POWDER FORM
UV FILTERS IN POWDER FORM Publication Number: WO/2005/084631 International Application No.: PCT/EP2005/001244 Publication Date: 15.09.2005 International Filing Date: 08.02.2005 Int
Water soluble powder form compositions and their applications thereof
Title: Water soluble powder form compositions and their applications thereof United States Patent: 5,935,603 Inventors: Derrieu; Guy (Cagnes-sur-Mer, FR); Pougnas; Jean-Luc (Saint Laurent du Va