Synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker
Synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker
2006
Aya Shibata1, Yoshihito Ueno1,2, Akira Matsuda4 and Yukio Kitade1,2,3
1 Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan, 2 Center for Emerging Infectious Diseases, Gifu University, Yanagido, Gifu 501-1193, Japan, 3 Center for Advanced Drug Research, Gifu University, Yanagido, Gifu 501-1193, Japan, 4 Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
Nucleic Acids Symposium Series 2006
This paper describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stranded DNA or RNA in buffer solutions both with and without MgCl2. Thus, these oligonucleotides would be useful as antisense oligonucleotides for targeting single-stranded RNA through triplex formation.
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