Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules
Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules
Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw - Washington, DC, US
Inventors: Rina Goldshtein, Galina Ratner, Larisa Gitis, Boris Tulbovich
Class: 514002000 (USPTO)
Related Patents: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Peptide Containing (e.g., Protein, Peptones, Fibrinogen, Etc.) Doai
#20050227911
10/13/05
The present invention provides hydrophilic dispersions comprising nanoparticles of inclusion complexes consisting essentially of nanosized particles of a macromolecule wrapped in an amphiphilic polymer such that non-valent bonds are formed between the macromolecule and the amphiphilic polymer. The macromolecules may be a naturally-occurring, synthetic or recombinant polypeptide, protein, polysaccharide or polynucleotide, and the amphiphilic polymer is a polysaccharide or a modified polysaccharide such as starch, chitosan or an alginate.
FIELD OF THE INVENTION
[0002] The present invention is in the field of nanoparticles. More particularly, the invention relates to soluble nanosized particles consisting of inclusion complexes of an active macromolecule wrapped within a suitable amphiphilic polymer, and methods of producing said nanoparticles.
SUMMARY OF THE INVENTION
[0022] It has now been found by the present inventors that the technology of solumerization disclosed in the above-mentioned parent U.S. application Ser. Nos. 10/952,380 and 10/256,023, incorporated herewith by reference in their entirety, for small organic compounds, can be applied also for macromolecules.
[0023] The present invention thus relates to a hydrophilic inclusion complex consisting essentially of nanosized particles of a macromolecule wrapped in an amphiphilic polymer such that non-valent bonds are formed between the macromolecule and the amphiphilic polymer, wherein said amphiphilic polymer is a polysaccharide or a modified polysaccharide.
[0024] The present invention further relates to hydrophilic dispersions comprising nanoparticles of said inclusion complexes, to their preparation and to stable pharmaceutical compositions comprising said dispersions.
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