Bulking Up on Protein Drugs
JR Minkel, a freelance writer based in Brooklyn, N.Y.
DrugDiscovery & Development Magazine
The "cryo-coma" in the clinical protein manufacturing facility of Wyeth BioPha READ MORE http://www.dddmag.com/ShowPR.aspx...
Conformation-specific affinity purification of proteins using engineered binding proteins: Application to the estrogen receptor
June 2006
Jin Huanga, Akiko Koidea, Kendall W. Nettleb, Geoffrey L. READ MORE http://www.sciencedirect.com/science...
Protein stability in the presence of polymer degradation products: Consequences for controlled release formulations
June 2006
Amy S. Determana, Jennifer H. Wilsonb, Matt J. Kippera, Michael J. Wan READ MORE http://www.sciencedirect.com/science...
Biomimetic approaches to protein and gene delivery for tissue regeneration
Available online 22 May 2006.
Stelios T. Andreadis and David J. Geer
Trends in Biotechnology
Novel therapeutic strat READ MORE http://www.sciencedirect.com/science...
Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery
11 May 2006
Sunday A. Shoyele, and Alex Slowey
International Journal of Pharmaceutics
Abstract
Formulation READ MORE http://www.sciencedirect.com/science...
Strategies to improve plasma half life time of peptide and protein drugs
2006
Werle M; Bernkop-Schn?rch A
ThioMatrix GmbH, Research Center Innsbruck, Innsbruck, Austria
Amino Acids
Due to the o READ MORE http://www.medscape.com/medline/abstract/16622600...
Combined approach to the analysis of recombinant protein drugs using hollow-fiber flow field-flow fractionation, mass spectrometry, and chemiluminescence detection
2006
Roda A; Parisi D; Guardigli READ MORE http://www.medscape.com/medline/abstract/16478098...
Oral gene therapy: a novel method for the manufacture and delivery of protein drugs
2005
Rothman S; Tseng H; Goldfine I
University of California, San Francisco, San Francisco, California 94708, U READ MORE http://www.medscape.com/medline/abstract/15929688...
Microencapsulation peptide and protein drugs delivery system
2005
Dai C; Wang B; Zhao H
Key Laboratory of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioen READ MORE http://www.medscape.com/medline/abstract/15737536...
Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs
2005
Ke WT; Lin SY; Ho HO; She READ MORE http://www.medscape.com/medline/abstract/15653166...
Interspecies scaling of protein drugs: prediction of clearance from animals to humans
2004
Mahmood I
Division of Clinical Trial Design and Analysis, Office of Therapeutic Research and Review, Foo READ MORE http://www.medscape.com/medline/abstract/14648647...
Synthesis and characterization of biocompatible poly(organophosphazenes) aiming for local delivery of protein drugs
2006
Seong JY; Jun YJ; Kim BM; Park YM; Sohn YS
Department of Chemistry, Divisi READ MORE http://www.medscape.com/medline/abstract/16549280...
Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs
Sep 2005
Ching-Jou Lim
J Control Release
Oligomeric transferrin (Tf) was used to investi READ MORE http://www.medscape.com/medline/abstract/15964654...
Postfabrication encapsulation of model protein drugs in a negatively thermosensitive hydrogel
Aug 2005
Ying Zhang, Wen Zhu, Biaobing Wang, et. al.
J Pharm Sci
A postfabrication encapsulation t READ MORE http://www.medscape.com/medline/abstract/15986466...
Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta
Apr 2004
Tal Peleg-Shulman, Laila C Roisman, Gordin Zupkovitz
J Bi READ MORE http://www.medscape.com/medline/abstract/14960565...
Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2
October 2006
Lorenz Meinela, b, c, 1, Sand READ MORE http://www.sciencedirect.com/science...
Alginate?whey protein granular microspheres as oral delivery vehicles for bioactive compounds
September 2006
Lingyun Chena and Muriel Subirade
Biomaterials
Abstract
Alginate (AL)?whey protein READ MORE http://www.sciencedirect.com/science...
Glucose transporter proteins GLUT1 and GLUT3 like immunoreactivities in the fetal sheep brain are not reduced by maternal betamethasone treatment
7 August 2006
Iwa Antonow-Schlorkea, Martin Eberta READ MORE http://www.sciencedirect.com/science...
Arginine-rich intracellular delivery peptides noncovalently transport protein into living cells
4 August 2006
Ya-Hui Wanga, Chung-Pin Chena, Ming-Huan Chanb, Microsugar Changa, Yu-Wun Houa, Hwei- READ MORE http://www.sciencedirect.com/science...
Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantation
24 July 2006
Kazuhide Furuyaa, , , Nob READ MORE http://www.sciencedirect.com/science...
Incorporation of a model protein into chitosan-bile salt microparticles
2006 Apr 7
Lameiro MH, Lopes A, Martins LO, Alves PM, Melo E.
Int J Pharm.
In order to develop a mucosal delivery system READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Intracellular delivery of purine nucleoside phosphorylase (PNP) fused to protein transduction domain corrects PNP deficiency in vitro
2006 Aug 21
Toro A, Paiva M, Ackerley C, Grunebaum E.
Cell I READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Exogenous expression of proteins in neurons using the biolistic particle delivery system
2006
Gamper N, Shapiro MS.
Methods Mol Biol.
Exogenous expression of genes in mammalian neurons represe READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Tripep Produces Additional Positive Data for Its Hepatitis C DNA Vaccine Using Inovio's DNA Delivery System
August 28, 2006
Therapeutics Daily
SAN DIEGO--(BUSINESS WIRE)--Aug. 28, 2006 - Inovio B READ MORE http://www.therapeuticsdaily.com/news/article.cfm...
RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules
February 16, 2006
WEI-HONG YANG, JIANG HONG YU, TOD GULICK, KENNETH D. BLOCH3 and DONALD B. BLOCH
RNA
Th READ MORE http://www.rnajournal.org/cgi/content/abstract/12/4/547
Potential Biologic Therapies for the Intervertebral Disc
2006
Christopher Evans, PhD, DSc
JB&JS
The author did not receive grants or outside funding in support of his research for or preparatio READ MORE http://www.ejbjs.org/cgi/content/abstract/88/suppl_2/95
A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALA
2006 Sep 29
Min SH, Lee DC, Lim MJ, Park HS, Kim DM, Cho CW, Yoon DY, Yeom YI.
J Gene Med.
BACKG READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Saporin as a novel suicide gene in anticancer gene therapy
2006 Sep 29
Zarovni N, Vago R, Solda T, Monaco L, Fabbrini MS.
Cancer Gene Ther.
We used a non-viral gene delivery approach to explore READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Amine-Functionalized Sba-15 on Protein Delivery: Adsorption, Release and Stability of Bovine Serum Albumin
16 November 2006
Shiwei Song1, Kus Hidajat1, and Sibudjing Kawi2. (1) Department of Chemi READ MORE http://aiche.confex.com/aiche/2006/techprogram/P71310.HTM
Systemic protein delivery by muscle-gene transfer is limited by a local immune response
1 June 2005
Lixin Wang, Eric Dobrzynski, Alexander Schlachterman, Ou Cao, and Roland W. Herzog
Blood First READ MORE http://www.bloodjournal.org/cgi/content/full/105/11/4226
Delivery of antibody-captured proteins into living cells using PTD-fused protein A
June 28, 2006
Masayasu Mie, Kazuto Mori, Hisakage Funabashi and Eiry Kobatake
Springer
Abstract Protein trans READ MORE http://www.springerlink.com/content/m2x860tq2624j54w/
Amphiphilic Self-assembled Nanoparticles Composed of Chitosan and Ursolic Acid for Protein Delivery on the Skin
2006
S.B. Lee, K. Cho and J.K. Shim
Korea Institute of Industrial Technology, KR
READ MORE http://www.nsti.org/Nanotech2006/showabstract.html...
Nanotech could improve protein delivery
24/03/2004
Decision News Media SAS
Access Pharmaceuticals has signed an agreement with an unnamed US partner for a drug delivery system based on nanoparti READ MORE http://www.drugresearcher.com/news/ng.asp...
Biodegradable Microspheres as Carriers for Native Superoxide Dismutase and Catalase Delivery
November 5, 2004
Stefano Giovagnoli,1 Paolo Blasi,1 Maurizio Ricci,1 and Carlo Rossi1
1Department READ MORE http://www.aapspharmscitech.org/view.asp...
An intracellular delivery vehicle for protein transduction of micro-dystrophin
2005 Feb
Richard H Weisbart, James E Hansen, Robert N Nishimura, Grace Chan, Rika Wakelin, Sophia S Chang, Larry Bare READ MORE http://lib.bioinfo.pl/pmid:15823959
The RA Domain of Ste50 Adaptor Protein Is Required for Delivery of Ste11 to the Plasma Membrane in the Filamentous Growth Signaling Pathway of the Yeast
February 2006
Dagmar M. Truckses, Joshua E. READ MORE http://mcb.asm.org/cgi/content/abstract/26/3/912
Trans-Golgi network delivery of synaptic proteins in synaptogenesis
2004
Vladimir Sytnyk*, Iryna Leshchyns'ka*, Alexander Dityatev and Melitta Schachner
The Company of Biologists
Synapse forma READ MORE http://jcs.biologists.org/cgi/content/full/117/3/381...
New Family Of Biodegradable Polymers Shows Promise For Intracellular Drug Delivery
30 Mar 2006
Medical News Today
A newly developed family of biodegradable polymers has shown potential for use i READ MORE http://www.medicalnewstoday.com/medicalnews.php...
Nanoparticulate Drug Delivery Systems Based on Hydrotropic Polymers, Dendrimers, and Polymer Complexes
2005
J.H. Park, K.M. Huh, S.C. Lee, W-K Lee, T. Ooya and K. Park
Nanotech 2005
Novel nanopa READ MORE http://www.nsti.org/procs/Nanotech2005v1/3/W54.05
Successful parallel development and integration of a plasmid-based biologic, container/closure system and electrokinetic delivery device
Available online 24 August 2005.
Henry Hebela, , Heather A READ MORE http://www.sciencedirect.com/science...
The biological significance of lipid-protein interactions
Engineering Village 2
2006 Elsevier Inc.
Accession number: 8992911
Title: The biological significance of lipid-protein interactio READ MORE http://www.engineeringvillage2.org
Multiple alignment of protein sequences with repeats and rearrangements
2006 Oct 26
Phuong TM, Do CB, Edgar RC, Batzoglou S.
Department of Computer Science, Posts & Telecommunications Institute READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
SISYPHUS--structural alignments for proteins with non-trivial relationships
2006 Oct 26
Andreeva A, Prlic A, Hubbard TJ, Murzin AG.
MRC Centre for Protein Engineering Hills Road, Cambridge CB2 2 READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Evaluation of critical formulation parameters influencing the bioactivity of ?-lactamases entrapped in pectin beads
Received 16 February 2006; revised 23 May 2006; accepted 25 May 2006. Availabl READ MORE http://www.sciencedirect.com/science...
In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate
Received 10 April 2006; revised 8 August 2006; accepted 14 August 2006. Available online 18 READ MORE http://www.sciencedirect.com/science...
Is the oral route possible for peptide and protein drug delivery?
2006 Oct
Morishita M, Peppas NA.
Drug Discov Today.
Oral delivery of peptides and proteins remains an attractive alternative to READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Nanotechnologies in protein delivery
2006 Sep-Oct
Salmaso S, Bersani S, Semenzato A, Caliceti P.
J Nanosci Nanotechnol.
The growth rate for biotech drugs, namely proteins, peptides, and oligonu READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Core/Shell nanoparticles with lecithin lipid cores for protein delivery
2006 Aug
Oh KS, Han SK, Lee HS, Koo HM, Kim RS, Lee KE, Han SS, Cho SH, Yuk SH.
Biomacromolecules.
Core/shell nanoparticl READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Stem cell-derived erythroid cells mediate long-term systemic protein delivery
2006 Aug
Chang AH, Stephan MT, Sadelain M.
Nat Biotechnol.
We demonstrate here the capacity of erythroid cells to READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Fucosphere--new microsphere carriers for peptide and protein delivery: preparation and in vitro characterization
2006 Aug
Sezer AD, Akbuga J.
J Microencapsul.
PURPOSE: Fucoidan is a complex pol READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Development of phosphorylated glucomannan-coated chitosan nanoparticles as nanocarriers for protein delivery
2006 Sep-Oct
Cuna M, Alonso-Sandel M, Remunan-Lopez C, Pivel JP, Alonso-Lebrero JL, Alo READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Different ratios of lactide and glycolide in PLGA affect the surface property and protein delivery characteristics of the PLGA microspheres with hydrophobic additives
2006 Feb
Chung TW, Tsai YL, H READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Polyarginine-mediated protein delivery to dendritic cells presents antigen more efficiently onto MHC class I and class II and elicits superior antitumor immunity
2006 Aug
Mitsui H, Inozume T, Kita READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
2006 May
Ratajczak J, Miekus K, Kucia M, Zhang J, Reca READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
2005 Nov
Benn SC, Ay I, Bastia E, Chian RJ, Celia SA, Pepinsky RB, Fishman PS, Brown RH READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
TAT-mediated endocytotic delivery of the loop deletion Bcl-2 protein protects neurons against cell death
2005 Oct
Soane L, Fiskum G.
J Neurochem.
Protein delivery mediated by protein transduct READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Chronic gene delivery of interferon-inducible protein 10 through replication-competent retrovirus vectors suppresses tumor growth
2005 Nov
Sun Y, Finger C, Alvarez-Vallina L, Cichutek K, Buchholz READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclas READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Normal flora: living vehicles for non-invasive protein drug delivery
2004 Nov 22
Shao J, Kaushal G.
Int J Pharm.
Feasibility to use probiotic bacteria as a living protein delivery system throu READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
A novel method for the preparation of biodegradable microspheres for protein drug delivery
2006 Aug 22
Pareta R, Edirisinghe MJ.
J R Soc Interface.
Microspheres are potential candidates for READ MORE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi...
Nano-submarines for drug delivery
21-05-2007
Thijs Westerbeek
Radio Netherlands
War-submarines that travel through our bodies looking for alien invaders; molecular battle ships that know exactl READ MORE http://www.radionetherlands.nl/features/science/RF070521
Avecia paves way for more efficient protein production
08/05/2007
by Pete Mansell
DrugResearcher.com
This news is provided by:
In-PharmaTechnologist.com
The Biologics division of UK company READ MORE http://www.drugresearcher.com/news/ng.asp...
SAFC completes protein purification capacity expansion
03/05/2007
By Emilie Reymond
In-PharmaTechnologist.com
This news is provided by:
DrugResearcher.com
SAFC Pharma, the contract manufactur READ MORE http://www.in-pharmatechnologist.com/news/ng.asp...