mTOR kinase-associated proteins

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mTOR kinase-associated proteins
United States Patent 7,052,870
Sabatini , et al.
May 30, 2006
Inventors: Sabatini; David M. (Cambridge, MA); Kim; Do-Hyung (Cambridge, MA); Sarbassov; Dos D. (Shrewsbury, MA)
Assignee: Whitehead Institute for Biomedical Research (Cambridge, MA)
Appl. No.: 782244
Filed: February 18, 2004
Abstract
The invention describes isolated mTOR-associated proteins ("mTOR-APs") as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.