Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms

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Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms
United States Patent 7,060,429
Krueger , et al.
June 13, 2006
Inventors: Krueger; Bruce K. (Ellicott City, MD); Kingsbury; Tami J. (Baltimore, MD); Bambrick; Linda L. (Baltimore, MD); Dorsey; Susan G. (Frederick, MD)
Assignee: University of Maryland, Baltimore (Baltimore, MD)
Appl. No.: 645546
Filed: August 22, 2003
Abstract
This invention relates to a method of treating or preventing neuro-degenerative disorders and neuro-developmental disorders by altering the ratio of the amount of full-length TrkB polypeptide to the amount of truncated TrkB polypeptides in a neuron or by altering the ratio of the amount of full-length TrkC polypeptide to the amount of truncated TrkC polypeptides in a neuron.