Transporting silence: Design of carriers for siRNA to angiogenic endothelium - siRNA

Transporting silence: Design of carriers for siRNA to angiogenic endothelium
5 December 2005
Raymond M. Schiffelersa, , , Archibald J. Mixsonb, Aslam M. Ansaric, Marcel H.A.M. Fensa, Quingquan Tangc, Qin Zhouc, Jun Xuc, Grietje Molemad, Patrick Y. Luc, Puthupparampil V. Scariac, Gert Storma and Martin C. Woodle
Journal of Controlled Release
Abstract
The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several hurdles must be overcome including rapid clearance, nuclease degradation, and inefficient intracellular localization. In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis.
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