Thermodynamic properties underlying the a-helix-to-?-sheet transition, aggregation, and amyloidogenesis of polylysine as probed by calorimetry, densimetry, and ultrasound velocimetry
Thermodynamic properties underlying the a-helix-to-?-sheet transition, aggregation, and amyloidogenesis of polylysine as probed by calorimetry, densimetry, and ultrasound velocimetry
Engineering Village 2
2006 Elsevier Inc
Accession number: 8887768
Title: Thermodynamic properties underlying the a-helix-to-?-sheet transition, aggregation, and amyloidogenesis of polylysine as probed by calorimetry, densimetry, and ultrasound velocimetry
Authors: Smirnovas, V.1 ; Winter, R.1 ; Funck, T.; Dzwolak, W.
Author affiliation: 1 Dept. of Chem., Dortmund Univ., Germany
Serial title: Journal of Physical Chemistry B
Abbreviated serial title: J. Phys. Chem. B (USA)
Volume: 109
Issue: 41
Publication date: 20 Oct. 2005
Pages: 19043-5
Language: English
ISSN: 1089-5647
CODEN: JPCBFK
Document type: Journal article (JA)
Publisher: ACS
Country of publication: USA
Material Identity Number: G111-2005-043
Abstract: In this work, we performed a detailed thermodynamic study of an aggregation-prone polypeptide, polylysine, to gain a deeper insight into the scenario of physicochemical events during its unfolding, aggregation, and amyloidogenesis. The precise and simultaneous determination of the partial molar volume, the heat capacity, and the coefficients of thermal expansion, as well as adiabatic and isothermal compressibility of the protein upon unfolding and aggregation, yields a thermodynamic picture of the aggregation process highlighting the importance of volume fluctuations during unfolding and amyloidogenesis of proteins
Number of references: 9
Inspec controlled terms: aggregation - bioacoustics - biothermics - calorimetry - densitometry - molecular biophysics - polymers - proteins - specific heat - thermal expansion - thermodynamic properties - ultrasonic velocity
Uncontrolled terms: thermodynamic properties - a-helix-?-sheet transition - amyloidogenesis - polylysine - calorimetry - densimetry - ultrasound velocimetry - aggregation-prone polypeptide - physicochemical events - molar volume - heat capacity - thermal expansion coefficients - adiabatic compressibility - isothermal compressibility - protein
Inspec classification codes: A8715B Biomolecular structure, configuration, conformation, and active sites - A8260 Chemical thermodynamics - A8750B Interactions of biosystems with radiations - A8716 Biothermics
Treatment: Experimental (EXP)
Discipline: Physics (A)
DOI: 10.1021/jp053283w
Database: Inspec
Copyright 2006, The Institution of Engineering and Technology
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