The influence of the use of viscosifying agents as dispersion media on the drug release properties from PLGA nanoparticles

The influence of the use of viscosifying agents as dispersion media on the drug release properties from PLGA nanoparticles
November 2004
Received 12 December 2003; Revised 22 March 2004; accepted 22 March 2004. Available online 2 June 2004.
Kathleen Dillen, Wim Weyenberg, Jo Vandervoort and Annick Ludwig
European Journal of Pharmaceutics and Biopharmaceutics
Volume 58, Issue 3
ScienceDirect
Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp (Wilrijk), Belgium
Abstract
Poly(lactide-co-glycolide) nanoparticles incorporating ciprofloxacin HCl were prepared by means of a W/O/W emulsification solvent evaporation method. The physicochemical properties of these particles were evaluated by measuring particle size, zeta potential and drug loading efficiency. Gamma-sterilised nanoparticles were dispersed in different isoviscous polymer solutions, commonly used as vehicles in eye drops. The influence of -irradiation of the viscosifying agents on the drug release properties of the dispersed nanoparticles was evaluated with respect to release in mannitol solution. The viscosity of the polymer solutions prepared was measured by flow rheometry and thereby the influence of temperature and sterilisation by autoclaving on viscosity was examined. Before and after freeze-drying and subsequent sterilisation by gamma-irradiation, the polymer solutions were also characterised by dynamic stress sweep and dynamic frequency sweep oscillation measurements to deduce possible structural changes. A possible relationship between the differences in ciprofloxacin release from the nanoparticles suspended in the various media and the network structure or rheological behaviour of the polymers was investigated.
Author Keywords: PLGA; Nanoparticles; Ciprofloxacin; Drug release; Rheology
Corresponding author. Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, Antwerp (Wilrijk) 2610, Belgium. Tel.: +32-3-820-27-16; fax: +32-3-820-27-34
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