The Effects of Intravenous Lidocaine on Pain During Injection of Medium- and Long-Chain Triglyceride Propofol Emulsions

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ANESTHETIC PHARMACOLOGY:
The Effects of Intravenous Lidocaine on Pain During Injection of Medium- and Long-Chain Triglyceride Propofol Emulsions
Jun 2005
Woon Si Yew, Shin Yuet Chong, Kian Hian Tan, and Meng Huat Goh
Anesthesia & Analgesia
Abstract:
Propofol formulated in medium- and long-chain tri-glycerides (MCT/LCT) is thought to cause less pain on injection. In this study we sought to determine if adding lidocaine to propofol-MCT/LCT is more effect-ive in decreasing pain compared with propofol-MCT/LCT alone or conventional propofol-lidocaine mixtures. Seventy-five patients were randomized into three groups. Group A received conventional propofol-lidocaine mixtures with 20 mg lidocaine, group B received propofol-MCT/LCT with saline, and group C received propofol-MCT/LCT with 20 mg lidocaine. The incidence of pain was 24% in groups A and B and 4% in group C. The number needed to treat to prevent pain was 5. We conclude that propofol-MCT/LCT-lidocaine mixtures significantly reduce pain.
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