THIO-siRNA APTAMERS

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THIO-siRNA APTAMERS
Inventor: GORENSTEIN DAVID G (US); YANG XIAN BIN (US)
Applicant: UNIV TEXAS (US); GORENSTEIN DAVID G (US);
IPC: C07H21/02; C07H21/00
Publication info: WO2006044663
Date: 2006-04-27
Abstract of WO2006044663
The present invention includes thioaptamers that are partially thio-modified, methods and compositions for the isolation, selection, improvement, characterization and use of RNA and DNA thioaptamers for gene silencing, including degradative and non-degradative interference with translation.