Substituted indoles - Patent Pending

United States Patent Application 20050153980
Kind Code A1
Schadt, Oliver ; et al. July 14, 2005
Substituted indoles
Abstract
Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R.sup.1, D, E, R.sup.12, p, X.sup.1, E, G, X.sup.2 and Z are as defined in claim 1, exhibit particular actions on the central nervous system, especially 5HT reuptake-inhibiting and 5 HTx-agonistic and/or -antagonistic actions and in particular serotonin-agonistic and -antagonistic properties and can be employed as antipsychotics, neuroleptics, antidepressants, anxiolytics and/or antihypertonics. They can furthermore be employed as excitatory amino acid antagonists for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or psychoses 1
Inventors: Schadt, Oliver; (Rodenbach, DE) ; Boettcher, Henning; (Darmstadt, DE) ; Leibrock, Joachim; (Pfungstadt, DE) ; Schiemann, Kai; (Seeheim-Jugenheim, DE) ; Heinrich, Timo; (Gross-Umstadt, DE) ; Hoelzemann, Gunter; (Seeheim-Jugenheim, DE) ; van Amsterdam, Christoph; (Darmstadt, DE) ; Bartoszyk, Gerd; (Weiterstadt, DE) ; Seyfried, Christoph; (Seeheim-Jugenheim, DE)
Correspondence Name and Address: MILLEN, WHITE, ZELANO & BRANIGAN, P.C.
2200 CLARENDON BLVD.
SUITE 1400
ARLINGTON
VA
22201
US
Serial No.: 511155
Series Code: 10
Filed: October 14, 2004
PCT Filed: April 11, 2003
PCT NO: PCT/EP03/03806
U.S. Current Class: 514/254.09; 514/323; 544/373; 546/201
U.S. Class at Publication: 514/254.09; 514/323; 546/201; 544/373
Intern'l Class: A61K 031/496; A61K 031/454; C07D 043/02