Structure analysis of oligonucleotide in organic solvent
Structure analysis of oligonucleotide in organic solvent
2006
Hiroshi Abe, Naoko Abe and Yoshihiro Ito
Nanomedical Engineering Laboratory, Discovery Research Institure, Riken, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Nucleic Acids Symposium Series 2006
Oligonucleotide has been used as functional molecule such as recording device, or catalyst for chemical reaction. However, that utility has been limited, because it is only soluble in water. Recently, we succeeded in making chemically modified DNA which is clearly soluble in organic solvent. Using this technique, G-quadruplex was constructed in non-polar organic solvent such as 1,2-dichloroethane. The structure was analyzed by CD spectra.
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