Stable liquid and lyophilized formulation of proteins - Patent Pending

Stable liquid and lyophilized formulation of proteins
Engineering Village
Publication number: US20060008415

Application number: 11166906

Unstandardized application number: 166906

Patent authority: US

Kind: A1 - Utility Patent Application

Title: Stable liquid and lyophilized formulation of proteins

Inventors: Zhou, Weichang (US) ; Gupta, Supriya (US) ; Liu, Naichi (US) ; Kaisheva, Elisabet A. (US) ; Powers, Patrick (US) ; Weinkam, Robert (US) ; Ramakrishnan, Vanitha (US)

Assignee: Protein Design Labs, Inc.

Publication date: 01/12/2006

Publication year: 2006

Filing date: 06/24/2005

Abstract: The present invention is directed to stable protein derivatives, e.g., antibodies, antibody fragments or peptides, with at least one free thiol group coupled to N-acetyl-L-cysteine, N-ethyl-maleimide, or cysteine and the methods of making such derivatives. In addition, stable liquid pharmaceutical formulations comprising such proteins or their derivatives and stable lyophilized pharmaceutical formulations comprising such proteins are provided. The present invention is also directed to a method of making a stable Fab' fragment of an antibody and a method of controlling vascularization in injured or cancerous tissue comprising applying to the injured tissue one or more doses of the pharmaceutical formulations.

Document type: US Application

IPC-8 Code: A61K 51/00 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Preparations containing radioactive substances for use in therapy or testing in vivo 6

A61K 39/395 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing antigens or antibodies materials for immunoassay 2
Antibodies agglutinins ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum 3

US Classification: 424/130.1 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL

424/1.49 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
RADIONUCLIDE OR INTENDED RADIONUCLIDE CONTAINING; ADJUVANT OR CARRIER COMPOSITIONS; INTERMEDIATE OR PREPARATORY COMPOSITIONS
Attached to antibody or antibody fragment or immunoglobulin; derivative

Database: US Patents

Compilation and indexing terms, ? 2006 LexisNexis Univentio B.V.
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