Stabilization of alum-adjuvanted immunologically active agents

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Stabilization of alum-adjuvanted immunologically active agents
Engineering Village
Publication number: US20060067943

Application number: 11237200

Unstandardized application number: 237200

Patent authority: US

Kind: A1 - Utility Patent Application

Title: Stabilization of alum-adjuvanted immunologically active agents

Inventors: Maa, Yuh-Fun (US) ; Sellers, Scott (US)

Publication date: 03/30/2006

Publication year: 2006

Filing date: 09/27/2005

Abstract: A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.

Document type: US Application

IPC-8 Code: A61K 48/00 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy 5

A61K 39/00 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing antigens or antibodies materials for immunoassay 2

A61K 39/12 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing antigens or antibodies materials for immunoassay 2
Viral antigens 2

A61K 39/02 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing antigens or antibodies materials for immunoassay 2
Bacterial antigens 2

A61K 31/715 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing organic active ingredients 2
Carbohydrates; Sugars; Derivatives thereof sorbitol 2,7
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters 2

A61K 31/7012 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing organic active ingredients 2
Carbohydrates; Sugars; Derivatives thereof sorbitol 2,7
Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid gluconic acid ; ascorbic acid 7

US Classification: 514/53 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
DESIGNATED ORGANIC ACTIVE INGREDIENT CONTAINING (DOAI)
Carbohydrate (i.e., saccharide radical containing) DOAI
Dissacharide

424/184.1 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
ANTIGEN, EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR (E.G., IMMUNOSPECIFIC VACCINE, IMMUNOSPECIFIC STIMULATOR OF CELL-MEDIATED IMMUNITY, IMMUNOSPECIFIC TOLEROGEN, IMMUNOSPECIFIC IMMUNOSUPPRESSOR, ETC.)

424/53 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
DENTIFRICES (INCLUDES MOUTH WASH)
Oxygen or chlorine releasing compound containing

Database: US Patents

Compilation and indexing terms, ? 2006 LexisNexis Univentio B.V.
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