Solid solution of an antifungal agent with enhanced bioavailability

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Title: Solid solution of an antifungal agent with enhanced bioavailability
United States Patent: 5,972,381
Inventors: Sangekar; Surendra A. (Union, NJ); Lee; Ping I. (Radnor, PA); Vadino; Winston A. (Whitehouse Station, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Appl. No.: 882716
Filed: June 25, 1997
Abstract
A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of the formula I:
wherein: X is F; and R1 is
or an ester or ether of said compound of Formula I; and a soluble or insoluble polymer such as: povidone or crospovidone, wherein the ratio of said compound to said polymer is about 1:3 to about 1:6 is disclosed.