Solid solution beadlet - Patent Articles

Title: Solid solution beadlet
United States Patent: 6,692,767
Issued: February 17, 2004
Inventors: Burnside; Beth A. (Silver Spring, MD); McGuinness; Charlotte M. (Bethesda, MD); Rudnic; Edward M. (North Potomac, MD); Couch; Richard A. (Bethesda, MD); Guo; Xiaodi (Derwood, MD); Tustian; Alexander K. (Bothell, WA)
Assignee: Shire Laboratories Inc. (Rockville, MD)
Appl. No.: 156464
Filed: September 18, 1998
Abstract
Disclosed is a beadlet comprising (i) a hydrophobic long chain fatty acid or ester material; (ii) a surfactant; and (iii) a therapeutic agent which in admixture form a solid solution at room temperature. The hydrophobic material preferably has a melting point of about 40 to about 100oC., and is most preferably glyceryl behenate. The surfactant is preferably a polyglycolyzed glyceride, polyoxyethylene sorbate, ethylene or propylene block copolymer or combinations thereof, and is most preferably polyoxyethylene 20 sorbitan monolaurate.