Solid pharmaceutical dispersions

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Title: Solid pharmaceutical dispersions
United States Patent: 6,677,362
Issued: January 13, 2004
Inventors: Ghebre-Sellassie; Isaac (Morris Plains, NJ); Reisch, Jr.; Robert (Butler, NJ); Parikh; Riten (Randolph, NJ); Fawzi; Mahdi B. (Flanders, NJ); Nesbitt; Russell U. (Somerville, NJ)
Assignee: Warner-Lambert Company (Morris Plains, NJ)
Appl. No.: 218495
Filed: March 28, 1994
Abstract
A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.