Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations - Biologics Delivery

Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
Received 23 February 2006; revised 5 June 2006; accepted 6 June 2006. Available online 10 June 2006.
Maria Antonietta Casadei, a, , Felice Cerretoa, Stefania Cesaa, Maria Giannuzzoa, Michelle Feeneya, Carlotta Marianeccia and Patrizia Paolicellia
International Journal of Pharmaceutics
Volume 325, Issues 1-2 , 15 November 2006
ScienceDirect
aDipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universit? ?La Sapienza?, 00185 Rome, Italy
Abstract
Solid lipid nanoparticles (SLN) containing or not (S)-(+)-2-(4-isobutylphenyl)propionic acid (ibuprofen) were prepared with Preciol ATO 5 as lipid phase by the hot homogenization technique and characterized through particle size analyses and zeta potential measurements. DSC experiments carried out on the freeze-dried samples of loaded SLN showed a shift of the melting endotherm of the lipid phase, with the maximum at a temperature value higher then that of the?empty? SLN. 1H NMR of the nanosuspension allowed to calculate the encapsulation efficiency of the particles that was 52 ? 3%. By adding dextran methacrylate (DEX-MA) to the aqueous phase and submitting the mixture to UV irradiation, systems of SLN (drug-loaded and unloaded) incorporated into a dextran hydrogel were prepared. Finally, dissolution studies of ibuprofen from the freeze-dried samples were performed. The comparison among the release profiles of ibuprofen from SLN, DEX-MA hydrogel and SLN/DEX-MA-hydrogel allows to affirm that this last system, retaining about 60% of the drug after 2 h in acid medium and releasing it slowly in neutral solution, is suitable for modified delivery oral formulations.
Keywords: Solid lipid nanoparticles; Dextran methacrylate; Photochemical cross-linking reaction; Ibuprofen; Controlled release

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