STABILIZATION OF ALUM-ADJUVANTED IMMUNOLOGICALLY ACTIVE AGENTS

/Home/Lyophilization and Protein Formulation Patents/Patent Articles - Lyophilization

STABILIZATION OF ALUM-ADJUVANTED IMMUNOLOGICALLY ACTIVE AGENTS
Inventor: MAA YUH-FUN (US); SELLERS SCOTT (US)
Applicant: ALZA CORP (US)
EC: A61K9/16H6F; A61K9/70
IPC: A61K9/19; A61K39/39; A61K47/26
Publication info: WO2006037070
Date: 2006-04-06
Abstract of WO2006037070
A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.