RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)

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RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
Publication number: EP1710307
Publication date: 2006-10-11
Inventor: MCSWIGGEN JAMES (US); BEIGELMAN LEONID (US); CHOWRIRA BHARAT (US); PAVCO PAMELA (US); FOSNAUGH KATHY (US); JAMISON SHARON (US); USMAN NASSIM (US); THOMPSON JAMES (US)
Applicant: SIRNA THERAPEUTICS INC (US)
Classification:
- international: C12N15/09; C12N15/11; A61K31/7088; A61K31/7105; A61K31/711; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61K47/48; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P37/00; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07H21/02; C07H21/04; C12P19/34; A61K38/00; C12N15/09; C12N15/11; A61K31/7088; A61K31/7105; A61K31/711; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61K47/48; A61K48/00; A61P1/00; A61P3/00; A61P11/00; A61P13/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P27/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07H21/00; C12P19/00; A61K38/00
- european: A61K47/48H4; C07H21/02
Application number: EP20060075987 20030220
Priority number(s): EP20030743684 20030220; US20020358580P 20020220; US20020363124P 20020311; US20020386782P 20020606; US20020406784P 20020829; US20020408378P 20020905; US20020409293P 20020909; US20030440129P 20030115

Abstract of EP1710307

The present invention concerns methods for reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.