Protein Delivery Systems

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Protein Delivery Systems
2006
N. A. Peppas and C. Donini
Encyclopedia of Biomaterials and Biomedical Engineering
More effective and tailored drug delivery systems
(DDS) are continuously investigated, tested, and, eventually,
marketed. In the last 30 yr, the pharmaceutical
industry has made substantial steps in this direction.
Drug products containing proteins and peptides, as
therapeutic agents, are a perfect example of these two
intimately correlated aspects: route of administration
and quality of life. In the past 60 yr, hormones, serum
proteins, and enzymes have been extensively used in
therapy as active ingredients.[1,2] But recently, molecular
biology and, especially, recombinant deoxyribonucleic
acid (DNA) technology have made tremendous
progress resulting in the availability of a wide variety
of peptide- and protein-based therapeutics for poorly
controlled diseases. For this class of drugs, however,
the parenteral route represents today the predominant
route of administration, as the bioavailability of alternative
routes is extremely low and variable.
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