Practical formulation and process development of freeze-dried products.

Practical formulation and process development of freeze-dried products.
2005
Schwegman JJ, Hardwick LM, Akers MJ., Baxter BioPharma Solutions, Bloomington, IN, USA.
Pharm Dev Technol. 2005;10(2):151-73.
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Abstract:
Freeze-drying science and technology continues to evolve and increase in importance because of the emergence of biotechnology drugs that are too unstable to be commercially available as ready-to-use solutions. As more new drug compounds need to be developed as freeze-dried products, this minireview article provides practical guidance and commentary on the latest literature articles on formulation and process development of freeze-dried products. This article contains a table that provides the quantitative formulations of all commercial freeze-dried protein pharmaceutical products through 2004.