Powder formation by atmospheric spray-freeze drying

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Powder formation by atmospheric spray-freeze drying
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Inventors:Wang, Zhaolin (Edmonton, CA, US)
Finlay, Warren H. (Edmonton, CA, US)
Application Number:318864 Filing Date:12/28/2005 Publication Date:06/22/2006
United States Patent 20060130355 Kind Code:A1
Abstract:A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.