Photochemical evaluation of dual fluorescence of a novel DNA groove binder

/Home/Biologics Delivery - Protein Synthesis/DNA - Protein Synthesis

Photochemical evaluation of dual fluorescence of a novel DNA groove binder
2006
Kazuo Tanaka1, Kazuki Tainaka1, Shohei Fujishima2 and Akimitsu Okamoto1,2
1 Frontier Research System, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, 2 Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan
Nucleic Acids Symposium Series 2006
We synthesized the fluorophore-tethered oligopeptide showing a dual fluorescence in water, and the ratiometric fluorescence change of the modified oligopeptide was induced by the binding to DNA. The equilibrium of the modified oligopeptide between two excited states, a locally excited (LE) state and an intramolecular charge transfer (ICT) state, was controlled depending to DNA structures.
Please visit the web site to view the article in its entirety.