Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments

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Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments
United States Patent 6,995,135
Kawabe , et al.
February 7, 2006
Inventors: Kawabe; Takumi (Numazu, JP); Kobayashi; Hidetaka (Shizuoka, JP)
Assignee: CanBas Co., Ltd. (Numazu, JP)
Appl. No.: 347145
Filed: January 17, 2003
Abstract
This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting G2 cell cycle checkpoint. Thus, invention compounds can be used to inhibit cell growth alone or be used in combination with a nucleic acid damaging treatment to inhibit cell growth.