ORAL DELIVERY SYSTEMS COMPRISING A DRUG/POLYMER COMPLEX

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ORAL DELIVERY SYSTEMS COMPRISING A DRUG/POLYMER COMPLEX
Inventor: DONG LIANG CHANG (US); HAN JASMINE E (US)
Applicant: ALZA CORP (US); DONG LIANG CHANG (US)
EC: A61K9/19
IPC: A61K9/00; A61K9/00
Publication info: WO2006007354
Date: 2006-01-19
Abstract of WO2006007354
This invention pertains to the enhanced delivery of orally administered pharmaceutical agents and methods, dosage forms and devices thereof. In particular, the invention is directed to methods including providing a low solubility drug having a pKa between about 6 and about 9; dissolving the low solubility drug in an aqueous solution, wherein a pH of the aqueous solution is less than about 6.0; dissolving a hydrophilic polymer in the aqueous solution, wherein the weight ratio of the hydrophilic polymer to the low solubility drug is less than or equal to about 0.15; lyophilizing the aqueous solution to obtain a lyophilized powder. Also disclosed are drug formulations made according to the method, and dosage forms that include the drug formulations.