Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon

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Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
United States Patent 7,105,333
Madison , et al.
September 12, 2006
Inventors: Madison; Edwin L. (San Diego, CA), Ong; Edgar O. (San Diego, CA)
Assignee: Deadreon Corporation (San Diego, CA)
Appl. No.: 10/112,221
Filed: March 27, 2002
Abstract
Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP9 are provided.