Novel method for delivery and intracellular synthesis of siRNA molecules

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C12P21/02 SECTION C CHEMISTRY; METALLURGY
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE fermentation processes to form a food composition , ; compounds in general, see the relevant compound class, e.g. , ; brewing of beer ; producing vinegar ; processes for producing enzymes ; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification 3
Preparation of peptides or proteins single-cell protein 3
having a known sequence of two or more amino acids, e.g. glutathione 3

G01N33/53 SECTION G PHYSICS
MEASURING counting ; TESTING
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES separating components of materials in general , , , ; apparatus fully provided for in a single other subclass, see the relevant subclass, e.g. ; measuring or testing processes other than immunoassay, involving enzymes or micro-organisms , ; investigation of foundation soil in situ ; monitoring or diagnostic devices for exhaust-gas treatment apparatus ; sensing humidity changes for compensating measurements of other variables or for compensating readings of instruments for variations in humidity, see or the relevant subclass for the variable measured; testing or determining the properties of structures ; measuring or investigating electric or magnetic properties of materials ; systems in general for determining distance, velocity or presence by use of propagation effects, e.g. Doppler effect, propagation time, of reflected or reradiated radio waves, analogous arrangements using other waves ; determining sensitivity, graininess, or density of photographic materials ; testing component parts of nuclear reactors
Investigating or analysing materials by specific methods not covered by the preceding groups
Biological material, e.g. blood, urine , , , take precedence; determining the germinating capacity of seeds ; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface 3,4
Immunoassay; Biospecific binding assay; Materials therefor medicinal preparations containing antigens or antibodies ; haptens in general, see the relevant places in class ; peptides, e.g. proteins, in general 4



US Classification: 530/350 CHEMISTRY: NATURAL RESINS OR DERIVATIVES; PEPTIDES OR PROTEINS; LIGNINS OR REACTION PRODUCTS THEREOF
PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES

435/69.1 CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY
MICRO-ORGANISM, TISSUE CELL CULTURE OR ENZYME USING PROCESS TO SYNTHESIZE A DESIRED CHEMICAL COMPOUND OR COMPOSITION
Recombinant DNA technique included in method of making a protein or polypeptide

435/6 CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY
MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP
Involving nucleic acid

435/320.1 CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY
VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)

536/23.1 ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES
ORGANIC COMPOUNDS (CLASS 532, SUBCLASS 1)
Carbohydrates or derivatives
Nitrogen containing
N-glycosides, polymers thereof, metal derivatives (e.g., nucleic acids, oligonucleotides, etc.)
DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)

435/7.1 CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY
MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP
Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay

435/325 CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY
ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE
Database: US Patents
Abstract: The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in methods of treating and preventing disease.