Nonphospholipid Vesicles of Carboplatin for Lung Targeting

Nonphospholipid Vesicles of Carboplatin for Lung Targeting
Apr-Jun 2003
B. Lu A1, J. Q. Zhang A1, H. Yang A1
Drug Delivery
Taylor & Francis
A1 West China School of Pharmacy, Sichuan University, Chengdu, China
Abstract:
Carboplatin (CPt) was incorporated into nonphospholipid vesicles (NPLV) by the method of membrane dispersion and its content determined spectrophotometrically. The particle size was between 2.0-10.0 wm with a mean value of 3.26 wm and a span of 0.55; and the drug content was 3.965 mg/ml. Dynamic dialysis was used for in vitro release of CPt and the results indicated that the drug release t1/2 was increased eight times, compared with the original drug. These parameters had little change after lyophilization. When tested with mice, the body distribution parameters showed obviously lung targeting characteristics. The S-180 lung neoplasm models were established by intravenous cancer cells in mice and the number of pulmonary nodules examined for evaluation of the therapeutic efficacy. Antitumor effect was increased and differed significantly (p < .05) compared with the original drug of the same dose.
Keywords:
Carboplatin, Lung Targeting, Nonphospholipid Vesicles, Sustained Release
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