Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms
Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms
Engineering Village 2
2006 Elsevier Inc.
Accession number: 8915044
Title: Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms
Authors: Palmer, G.M.1 ; Ramanujam, N.1
Author affiliation: 1 Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Serial title: Applied Optics
Abbreviated serial title: Appl. Opt. (USA)
Volume: 45
Issue: 5
Publication date: 10 Feb. 2006
Pages: 1062-71
Language: English
ISSN: 0003-6935
CODEN: APOPAI
Document type: Journal article (JA)
Publisher: Opt. Soc. America
Country of publication: USA
Material Identity Number: A132-2006-007
Abstract: A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the forward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption (0-20 cm-1) and reduced scattering coefficients (7-33 cm-1). Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350-850 nm. It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3% or less for phantoms containing hemoglobin and 12% or less for phantoms containing Nigrosin
Number of references: 21
Inspec controlled terms: absorption coefficients - bio-optics - biological tissues - calibration - light scattering - molecular biophysics - Monte Carlo methods - phantoms - physiological models - proteins - reflectivity - spectrophotometry - turbidity
Uncontrolled terms: Monte Carlo-based model - inverse model - tissue optical properties - synthetic phantoms - diffuse reflectance - absorption properties - scattering properties - turbid media - human tissues - calibration measurement - condensed Monte Carlo method - liquid-tissue phantoms - Nigrosin - hemoglobin - polystyrene spheres - absorption coefficients - scattering coefficients - Mie theory - spectrophotometer - diffuse reflectance spectra - 350 to 850 nm
Inspec classification codes: A8710 General, theoretical, and mathematical biophysics - A8750B Interactions of biosystems with radiations - A8715M Interactions with radiations at the biomolecular level - A0250 Probability theory, stochastic processes, and statistics - A0620H Measurement standards and calibration
Numerical data indexing: wavelength 3.5E-07 8.5E-07 m
Treatment: Theoretical or Mathematical (THR); Experimental (EXP)
Discipline: Physics (A)
DOI: 10.1364/AO.45.001062
Database: Inspec
Copyright 2006, The Institution of Engineering and Technology
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