Molecular method to augment RNA mediated gene silencing
Molecular method to augment RNA mediated gene silencing
Publication number: US2006189560
Publication date: 2006-08-24
Inventor: KUMAR AJIT (US)
Applicant:
Classification:
- international: A61K48/00; C12N15/87; A61K48/00; C12N15/87;
- european:
Application number: US20060340561 20060127
Priority number(s): US20060340561 20060127; US20050646992P 20050127
Abstract of US2006189560
The invention provides for a novel method of augmenting gene silencing via RNA interference (RNAi). Under the invention, RNAi technology is combined with the action of a variant nuclear factor to potently inhibit gene expression. In one embodiment of the invention, the nuclear factor is a variant of a double-stranded RNA (dsRNA) binding protein termed NF90ctv. The invention is also related to diagnostic/investigative and treatment methods and to cell lines produced by the methods disclosed.
Votes:35
Comments: 0