Modified carbon-paste electrodes as sensors for the determination of 1,4-benzodiazepines: Application to the determination of diazepam and oxazepam in biological fluids

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Modified carbon-paste electrodes as sensors for the determination of 1,4-benzodiazepines: Application to the determination of diazepam and oxazepam in biological fluids
Engineering Village 2
2006 Elsevier Inc.
Accession number: 8954702

Title: Modified carbon-paste electrodes as sensors for the determination of 1,4-benzodiazepines: Application to the determination of diazepam and oxazepam in biological fluids

Authors: Naranjo-Rodriguez, I.1 ; Lozano-Chaves, M.E.1 ; Palacios-Santander, J.M.1 ; Cubillana-Aguilera, L.M.1 ; Hidalgo-Hidalgo-de-Cisneros, J.L.1

Author affiliation: 1 Dept. de Quimica Analitica, Univ. de Cadiz, Spain

Serial title: Sensors and Actuators B (Chemical)

Abbreviated serial title: Sens. Actuators B, Chem. (Switzerland)

Volume: 115

Issue: 2

Publication date: 26 June 2006

Pages: 575-83

Language: English

ISSN: 0925-4005

CODEN: SABCEB

Document type: Journal article (JA)

Publisher: Elsevier

Country of publication: Switzerland

Material Identity Number: N867-2006-005

Abstract: The determination of benzodiazepines in biological fluids is object of great interest for many scientists. In the daily medical practice, it is necessary to perform drug analytical monitorization in order to adequate the dose of these substances to the necessities of the patients, and to avoid toxic effects. In forensic toxicology, benzodiazepines are often found in fatal cases of drug intoxication, as well as in the blood of drivers involved in traffic accidents. These reasons justify the necessity of developing new analytical methods for their determination. The main objective of this paper consists of the development of an electrochemical procedure to analyse benzodiazepines and/or their metabolites in a sensible, versatile and economic way, in biological fluids, such as plasma and urine. A whole electrochemical study of diazepam, temazepam and oxazepam using modified carbon-paste electrodes is reported. Using the optimal conditions for the voltammetric measurements of these pharmaceuticals, diazepam was determined in plasma and oxazepam in urine. Due to the complexity of these biological matrices, a previous solid-phase extraction (SPE) procedure was necessary to separate the active principles before their determination. The best results were obtained for the determination of oxazepam in urine. [All rights reserved Elsevier]

Number of references: 34

Inspec controlled terms: biological techniques - biomedical measurement - biosensors - electrodes - organic compounds - patient monitoring - voltammetry (chemical analysis)

Uncontrolled terms: carbon-paste electrodes - biological fluids - drug analytical monitorization - forensic toxicology - benzodiazepines - drug intoxication - diazepam - temazepam - oxazepam - voltammetric measurements - biological matrices - solid-phase extraction

Inspec classification codes: A8780B Biosensors - A0750 Electrical instruments and techniques - A8280F Electrochemical analytical methods - A8245 Electrochemistry and electrophoresis - B7230J Biosensors - B7510 Biomedical measurement and imaging

Treatment: Practical (PRA)

Discipline: Physics (A); Electrical/Electronic engineering (B)

DOI: 10.1016/j.snb.2005.10.021

Database: Inspec

Copyright 2006, The Institution of Engineering and Technology

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