Microencapsulated DNA for vaccination and gene therapy

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United States Patent Application 20050037085
Kind Code A1
Jones, David Hugh ; et al. February 17, 2005
Microencapsulated DNA for vaccination and gene therapy
Abstract
A microparticle contains DNA coding for a polypeptide and oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.
Inventors: Jones, David Hugh; (Salisbury, GB) ; Farrar, Graham Henry; (Salisbury, GB) ; Clegg, James Christopher Stephen; (Salisbury, GB)
Correspondence Name and Address: FISH & RICHARDSON PC
225 FRANKLIN ST
BOSTON
MA
02110
US

Assignee Name and Adress: Microbiological Research Authority, a United Kingdom corporation
Serial No.: 738122
Series Code: 10
Filed: December 17, 2003
U.S. Current Class: 424/489; 514/44
U.S. Class at Publication: 424/489; 514/044
Intern'l Class: A61K 048/00; A61K 009/14