Methods for tailoring the immune response to an antigen or immunogen

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Methods for tailoring the immune response to an antigen or immunogen
Engineering Village
Publication number: US20060035853

Application number: 11032487

Unstandardized application number: 032487

Patent authority: US

Kind: A1 - Utility Patent Application

Title: Methods for tailoring the immune response to an antigen or immunogen

Inventors: Whalen, Barbara J. (US) ; Kislauskis, Edward H. (US) ; Guberski, Dennis L. (US) ; Yang, Kejian (US)

Assignee: Oral Vaccine Technologies , Inc,; Biomedical Research Models, Inc.

Publication date: 02/16/2006

Publication year: 2006

Filing date: 01/07/2005

Abstract: The invention relates to methods and reagents for immunizing animals to elicit specific cellular and humoral immune-responses against specific antigens, such as viral antigens, including HBsAg antigen. The invention provides methods of using specifically prepared immunogen in fresh or lyophilized liposome, proper routes of administration of the immunogen, proper doses of the immunogen, and specific combinations of heterologous immunization including DNA priming in one administration route followed by liposome-mediated protein antigen boost in a different route to tailor the immune responses in respects of enhancing cell mediated immune response, cytokine secretion, humoral immune response, immune protection and selective skewing of T helper responses to be Th1, Th2, or a mixed or balanced Th response.

Document type: US Application

IPC-8 Code: A61K 48/00 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy 5

A61K 9/127 SECTION A HUMAN NECESSITIES
MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES bringing into special physical form ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; compounds per se , , , ; soap compositions ; micro-organisms per se
Medicinal preparations characterised by special physical form nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances
Dispersions; Emulsions 2,3
Liposomes 5

US Classification: 424/93.2 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
WHOLE LIVE MICRO-ORGANISM, CELL, OR VIRUS CONTAINING
Genetically modified micro-organism, cell, or virus (e.g., transformed, fused, hybrid, etc.)

514/44 DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS
DESIGNATED ORGANIC ACTIVE INGREDIENT CONTAINING (DOAI)
Carbohydrate (i.e., saccharide radical containing) DOAI
N-glycoside
Nitrogen containing hetero ring
Polynucleotide (e.g., RNA, DNA, etc.)

Database: US Patents

Compilation and indexing terms, ? 2006 LexisNexis Univentio B.V.
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