Method of producing a solid dispersion of a poorly water soluble drug

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Title: Method of producing a solid dispersion of a poorly water soluble drug
United States Patent: 5,985,326
Inventors: Butler; James Matthew (Romford, GB)
Assignee: ICOS Corporation (Bothell, WA)
Appl. No.: 952938
Filed: February 6, 1998
Abstract
Solid dispersions of poorly soluble drugs, such as (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-p yrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione and (+)-N-[1-(adamantanmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-be nzodiazepin-3-yl]-N'-phenylurea, methods of preparing the solid dispersions, and use of the solid dispersions in pharmaceutical compositions are disclosed.