METHODS TO PRODUCE LUNG SURFACTANT FORMULATIONS VIA LYOPHILIZATION AND FORMULATIONS AND USES THEREOF

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METHODS TO PRODUCE LUNG SURFACTANT FORMULATIONS VIA LYOPHILIZATION AND FORMULATIONS AND USES THEREOF
Publication Number: WO/2006/055532 International Application No.: PCT/US2005/041281
Publication Date: 26.05.2006 International Filing Date: 15.11.2005

Int. Class.: A61K 9/19 (2006.01), A61P 11/00 (2006.01), A61K 38/00 (2006.01)
Applicants: DISCOVERY LABORATORIES, INC. [US/US]; 2600 Kelly Road, Suite 100, Warrington, PA 18976 (US) (All Except US).
JOHNSON, Mark [US/US]; 1226 Gronwall Court, Los Altos, CA 94024 (US) (US Only).
COE, Roy [US/US]; 17 Hanover Court, Bordentown, NJ 08505-3119 (US) (US Only).
Inventors: JOHNSON, Mark [US/US]; 1226 Gronwall Court, Los Altos, CA 94024 (US).
COE, Roy [US/US]; 17 Hanover Court, Bordentown, NJ 08505-3119 (US).
Agent: REED, Janet, E.; Drinker Biddle & Reath LLP, One Logan Square, 18th and Cherry Streets, Philadelphia, PA 19103-6996 (US).
Priority Data: 60/628,365 15.11.2004 US
11/274,701 14.11.2005 US

Abstract:
Methods of producing lung surfactant formulations through solvent dissolution and lyophilization are described as well as surfactant formulations derived therefrom. Methods of treating respiratory distress dysfunction are also provided.