Lyophilization method and apparatus for producing particles - Patent Pending

Lyophilization method and apparatus for producing particles
US Patent & TradeMark Office
United States Patent Application 20040154317
Kind Code A1
Shekunov, Boris Y. ; et al. August 12, 2004
Abstract
A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
Inventors: Shekunov, Boris Y.; (Aurora, OH) ; Chattopadhyay, Pratibhash; (North Royalton, OH) ; Seitzinger, Jeffrey S.; (Broadview Heights, OH)
Correspondence Name and Address: RANKIN, HILL, PORTER & CLARK, LLP
925 EUCLID AVENUE, SUITE 700
CLEVELAND
OH
44115-1405
US

Assignee Name and Adress: Ferro Corporation
Cleveland
OH
44114

Serial No.: 434435
Series Code: 10
Filed: May 8, 2003
U.S. Current Class: 62/64; 34/285
U.S. Class at Publication: 062/064; 034/285
Intern'l Class: F25D 017/02; F26B 005/06
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