Liposomal formulation for oral administration of glutathione (reduced) - Patents

Liposomal formulation for oral administration of glutathione (reduced)
#20060099244
05/11/06

The invention is a composition administrable orally to provide systemic glutathione (reduced) and a method for providing systemic glutathione by oral administration of glutathione (reduced) in a liposome encapsulation. The administration of a therapeutically effective amount of oral liposomal glutathione (reduced) results in improvement of symptoms in disease states related to glutathione deficiency such as Parkinson's disease and cystic fibrosis. Compounds enhancing the effect of the liposomal glutathione are contemplated such as Selenium, EDTA, carbidopa, and levodopa.
CONTINUATION DATA
[0001] This application claims priority of U.S. Provisional Application No. 60/522,785 entitled Liposomal Formulation for Oral Administration of Glutathione (reduced) filed on Nov. 5, 2004, and claims priority of U.S. Provisional Application No. 60/597,041 entitled Liposomal Formulation for Oral Administration of Glutathione (Reduced), and is a continuation-in-part of those applications.
SUMMARY OF INVENTION
[0002] The invention is a composition of glutathione (reduced) in a liposome constructed to stabilize the glutathione in a physiologically active state which can be orally administered and delivers a therapeutically effective amount of glutathione (reduced) to improve symptoms in disease states by transfer of the glutathione into the cells of the body, and method of manufacture of the same. Previous art did not enable oral administration of glutathione (reduced) in a therapeutically effective way. The invention is also a method of encapsulating glutathione (reduced) in a liposome constructed to stabilize the glutathione in a physiologically active state and to enable the oral administration of a therapeutically effective amount of glutathione (reduced) to improve symptoms in disease states by transfer of the glutathione into the cells of the body. Compounds enhancing the effect of the liposomal glutathione are contemplated such as Selenium, EDTA, carbidopa and levodopa.
TECHNICAL FIELD
[0003] The invention relates to the field of delivery of a nutrient substance, glutathione in the biochemically-reduced form, in a liposomal preparation that allows the novel delivery mode of oral delivery of glutathione (reduced) in a sufficient amount to improve the condition of a disease state related to glutathione deficiency. The delivery may also be accomplished via absorption across the mucosa of the nose, mouth, gastrointestinal tract, after topical application for transdermal, or intravenous infusion.
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