LYOPHILIZED OR PRECIPITATED CEPHALOSPORIN ZWITTERION AND SALT COMPOSITION
(12) Patent: (11) CA 1307464
Application Number: (21) 551105
ABSTRACT:
ABSTRACT OF THE DISCLOSURE
Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solution of 7-[.alpha.-(2-amino-thiazol-4-yl)-.alpha.-(Z)-methoximinoacetamido]-3-[(1-methyl-1-pyrrolidinio)-methyl]-3-cephem-4-carboxylate zwitterion and a salt or mixture of salts from a selected particular group is a broad spectrum antibiotic composition and has better temperature stability at least up to 45?C than the zwitterion. The salt is one wherein the cation is selected from the group consisting of sodium, lithium, calcium, and magnesium and the anion is selected from the group consisting of chloride, bromide, and iodide. The molar ratio of zwitterion to salt ranges from about 0.5:1 to about 2:1.
72) Inventors (Country): KAPLAN, MURRAY ARTHUR (United States)
PALEPU, NAGESWARA RAO (United States)
BOGARDUS, JOSEPH BALLARD (United States)
(73) Owners (Country): BRISTOL-MYERS SQUIBB COMPANY (United States)
(71) Applicants (Country):
(74) Agent: GOWLING LAFLEUR HENDERSON LLP
(45) Issued: Sep. 15, 1992
(22) Filed: Nov. 5 , 1987
(41) Open to Public Inspection:
(52) Canadian Class (CPC): 167/187
(51) International Class (IPC): C07D 501/46
A61K 31/545
Patent Cooperation Treaty (PCT): No
(30) Application priority data: Application No. Country Date
001,945 United States Jan. 9 , 1987
Availability of licence: N/A
Language of filing: English
Votes:23
Comments: 0