LYOPHILIZED NATIVE GAMMA GLOBULIN PREPARATION FOR INTRAVENOUS ADMINISTRATION

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(12) Patent: (11) CA 1093965
Application Number: (21) 304887
ABSTRACT:
18/12
LYOPHILIZED NATIVE GAMMA GLOBULIN PREPARATION FOR INTRAVENOUS ADMINISTRATION
ABSTRACT OF THE DISCLOSURE
Freeze-drying of an aqueous solution of human native gamma globulin having an anticomplementary activity of 20 (C'H5O) or less in the presence of 0.06 to 0.26 part by weight of a neutral inorganic salt for 1 part by weight of the gamma globulin gives an immunoactive lyophilized native gamma globulin preparation which has undergone neither increase in anticomplementary activity nor deterioration in antibody activity during the freeze-drying and is safe for use in intravenous administration.
(72) Inventors (Country): SAKI, TOSHIYUKI (Japan)
FUJITA, SHIGERU (Japan)
NISHIDA, MASAYUKI (Japan)
YABUSHITA, SADAO (Japan)
(73) Owners (Country): THE GREEN CROSS CORPORATION (Japan)
(71) Applicants (Country):
(74) Agent: FETHERSTONHAUGH & CO.
(45) Issued: Jan. 20, 1981
(22) Filed: June 6 , 1978
(41) Open to Public Inspection:
(52) Canadian Class (CPC): 167/139
(51) International Class (IPC): A61K 35/14
A61K 39/395
Patent Cooperation Treaty (PCT): No
(30) Application priority data: Application No. Country Date
87128/77 Japan July 19, 1977
Availability of licence: N/A
Language of filing: English