LIPOSOMAL-POLYENE PRELIPOSOMAL POWDER AND METHOD FOR ITS PREPARATION - Patent Articles

(12) Patent: (11) CA 2099771
ABSTRACT:
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.
(72) Inventors (Country): LENK, ROBERT P. (United States)
MEHTA, REETA (United States)
LOPEZ-BERESTEIN, GABRIEL (United States)
(73) Owners (Country): THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS (United States)
ARGUS PHARMACEUTICALS, INC. (United States)
(71) Applicants (Country):
(74) Agent: FINLAYSON & SINGLEHURST
(45) Issued: Apr. 23, 2002
(86) PCT Filing Date: Jan. 10, 1992
(87) PCT Publication Date: July 23, 1992
Examination requested: Dec. 21, 1998
(51) International Class (IPC): A61K 9/127
A61K 47/24
A61K 31/71
Patent Cooperation Treaty (PCT): Yes (85) National Entry: June 29, 1993
(86) PCT Filing number: PCT/US1992/000160
(87) International publication number: WO1992/011842
(30) Application priority data: Application No. Country Date
640,707 United States Jan. 14, 1991
Availability of licence: N/A
Language of filing: English