Influence of small B-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets

Influence of B-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets
January 2003
Let?cia S. Koester, Clarissa R. Xavier, Paulo Mayorga and Valquiria L. Bassani
European Journal of Pharmaceutics and Biopharmaceutics, Volume 55, Issue 1, January 2003, Pages 85-91
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Abstract
The in vitro release profiles of carbamazepine and small beta, Greek-cyclodextrin either complexed or simply mixed and subsequently incorporated in hydrophilic matrix tablets containing 15 or 30% hydroxypropyl methylcellulose were evaluated. Solubility studies revealed a linear relationship between the increase in carbamazepine solubility and the increase in small beta, Greek-cyclodextrin concentration. Drying methods (spray-drying and freeze-drying) were used to obtain carbamazepine/small beta, Greek-cyclodextrin solid complexes in order to prepare tablets. The results demonstrated that matrix tablets containing carbamazepine/small beta, Greek-cyclodextrin solid complexes displayed faster carbamazepine and small beta, Greek-cyclodextrin release compared to that containing simple physical mixture. Gelling and matrix formation was impaired in formulation containing 15% hydroxypropyl methylcellulose and spray-dried complex. The comparison of spray-drying and freeze-drying revealed no significant influence of both drying methods on carbamazepine and small beta, Greek-cyclodextrin dissolution rate when carbamazepine/small beta, Greek-cyclodextrin complexes were incorporated in 30% hydroxypropyl methylcellulose matrix tablets. The results point to the possibility of modulating carbamazepine release using a hydroxypropyl methylcellulose matrix associated to the drug complexed with small beta, Greek-cyclodextrin.