In vitro selection of signaling aptamers

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In vitro selection of signaling aptamers
Inventor: ELLINGTON ANDREW D (US); JHAVERI SULAY D (US)
Applicant: RES DEV FOUNDATION (US)
EC: C12N15/10C4; C12Q1/68A8
IPC: C12N15/10; C12Q1/68; C12N15/10
Publication info: US2004086924
Date: 2004-05-06
Abstract of US2004018530
The CE-SELEX procedure of the present invention is a novel selection procedure that utilizes capillary electrophoresis (CE) in combination with conventional SELEX selection procedures. CE-SELEX, for the first time, allows selection to be performed in free solution. Performing selection against a target in free solution yields aptamers with improved affinity and/or improved selectivity toward target molecules for use as improved pharmaceuticals and diagnostic agents.