Hydrolysis and the Stabilization of Pharmaceuticals - Preventing and Dealing with Hydrolytic Reactions - July 28-29, 2005, PA

Hydrolysis and the Stabilization of Pharmaceuticals - Preventing and Dealing with Hydrolytic Reactions
July 28 - July 29 2005
The Ritz Carlton Philadelphia
Philadelphia , PA
Welcome to the first conference dedicated to Hydrolysis and the Stabilization of Pharmaceuticals. Even though hydrolysis is often seen as the most simple of the potential degradative pathways, it does not make it any less threatening to the stability of your product. Those working with water in pharmaceuticals know any amount of water, no matter how infinitesimal, can react with your drug product. Unforeseen humidity, climate and shipping conditions put stress on a compound beyond the normal standards. The mission of this program is to define knowledge gaps, learn about predictive models, and to provide solutions to produce a better drug product. We are delighted to organize the premier conference bringing together formulation, analytical science and packaging professionals to discuss best practices to prevent and deal with hydrolytic reactions.
The Hydrolysis and Stabilization Conference is part of IIR?s Stability Series which includes such topics as oxidative degradation, excipients, impurities, forced degradation, and photostability. The aim of the hydrolysis arm of the series is to go more in-depth in the areas of moisture activity, water processing, humidity, the environment and forced degradation. We are pleased to announce the following companies are members of our distinguished speaking faculty: Center for Pharmaceutical Physics, Colorcon, Eli Lilly, Hoffmann-La Roche, Merck & Company, Pfizer Pharmaceuticals, Quintiles, Inc., Spectral Dimensions, S?d-Chemie Performance Packaging, and the University of the Sciences in Philadelphia.
The first day of the conference is dedicated to defining the problem, gaining a better understanding of hyd rolysis, and increasing the physical stability of your drug product. The day opens with a brief course taught by the Un i versity of the Sciences in Philadelphia re v i ewing the basic information of hyd rolysis, the role of pH, buffer components and ionic strength, hyd rolysis of acidic, basic and neutral drugs, case studies of specific groups including ester, amide and ?-lactam hyd rolysis, and hyd rolysis in polymers and proteins. Speakers address creating the best possible formulations, surface acidity, and the use of predictive models to produce optimal drug candidates with key learnings fro m compounds with hyd rolytic issues.
The second day of the conference is dedicated to increasing the physical stability of your drug product and provides ways to prevent and deal hydrolytic reactions. A case study is presented on Merck?s novel approach for moisture measurement in solid dosage. This session serves as an introduction to moisture activity and the speaker discusses the limitations of traditional moisture measurement approaches and methods to measure moisture activity. Other topic areas being discussed includ headspace inside pharmaceutical packaging, near infrared chemical imaging, desiccants, film coating, and lyophilization.
Throughout the conference we hope to explore all considerations of hydrolysis in the development of a new drug product. Please register early as we expect this event to sell out. We look forward to greeting you from July 28-29 in Philadelphia!