Formulation of powder containing nanoparticles for aerosol delivery to the lungs

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Patent Number: US2005019270
Publication date: 2005-01-27
Inventor(s): FINLAY WARREN HUGH [CA]; ROA WILSON [CA]; LOEBENBERG RAIMAR [CA]
Applicant(s):
Requested Patent: US2005019270
Application Number: US20030624475 20030723
Priority Number(s): CA20032435632 20030721
IPC Classification: A61L9/04; A61K9/14
EC Classification: A61K9/00M20B, A61K9/16H6B
Equivalents: CA2435632
Abstract
Respirable particles carrying active principles or diagnostics in nanoparticle form are created by mixing the nanoparticles with liquid carrier, then forming the resultant mixture into respirable particles. Spray-drying, freeze spray drying and drying followed by comminution may be used to create the respirable particles, which may be delivered to the lung via a dry powder inhaler. In one example, lactose was used as the excipient and spray-dried with two different types of nanoparticle: gelatin and poly butylcyanoacrylate nanoparticles. The incorporation of nanoparticles did not affect the respirable fraction of the carrier powders.

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