Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control

Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control
August 2003
S. Pervez1, A. Mushtaq1 and M. Arif2
Journal of Radioanalytical and Nuclear Chemistry
Issue: Volume 257, Number 2
SpringerLink
(1) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Box, Nilore, Islamabad, Pakistan
(2) Bahauddin Zakariya University, Multan, Pakistan
Abstract The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed. Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTc-MAG3.
A. Mushtaq
Email: mushtaqa@pinstech.org.pk
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